node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acrB | mdtA_4 | SRM1_04429 | SRM1_04708 | Multidrug efflux pump subunit AcrB; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | Multidrug resistance protein MdtA precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.871 |
bepE | macB | SRM1_02793 | SRM1_01945 | Efflux pump membrane transporter BepE. | Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.460 |
bepE | mdtA_4 | SRM1_02793 | SRM1_04708 | Efflux pump membrane transporter BepE. | Multidrug resistance protein MdtA precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.881 |
cusS_4 | czcR_5 | SRM1_04711 | SRM1_04710 | Sensor kinase CusS; Member of a two-component regulatory system. | Transcriptional activator protein CzcR. | 0.968 |
cusS_4 | mdtA_4 | SRM1_04711 | SRM1_04708 | Sensor kinase CusS; Member of a two-component regulatory system. | Multidrug resistance protein MdtA precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.807 |
cusS_4 | mdtB_2 | SRM1_04711 | SRM1_04709 | Sensor kinase CusS; Member of a two-component regulatory system. | Multidrug resistance protein MdtB; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.802 |
czcR_5 | cusS_4 | SRM1_04710 | SRM1_04711 | Transcriptional activator protein CzcR. | Sensor kinase CusS; Member of a two-component regulatory system. | 0.968 |
czcR_5 | mdtA_4 | SRM1_04710 | SRM1_04708 | Transcriptional activator protein CzcR. | Multidrug resistance protein MdtA precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.800 |
czcR_5 | mdtB_2 | SRM1_04710 | SRM1_04709 | Transcriptional activator protein CzcR. | Multidrug resistance protein MdtB; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.802 |
macB | bepE | SRM1_01945 | SRM1_02793 | Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | Efflux pump membrane transporter BepE. | 0.460 |
macB | mdtA_4 | SRM1_01945 | SRM1_04708 | Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | Multidrug resistance protein MdtA precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | 0.912 |
macB | mexB | SRM1_01945 | SRM1_02837 | Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | Multidrug resistance protein MexB. | 0.620 |
macB | ttgB | SRM1_01945 | SRM1_01295 | Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | Putative efflux pump membrane transporter TtgB. | 0.412 |
mdtA_4 | acrB | SRM1_04708 | SRM1_04429 | Multidrug resistance protein MdtA precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Multidrug efflux pump subunit AcrB; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.871 |
mdtA_4 | bepE | SRM1_04708 | SRM1_02793 | Multidrug resistance protein MdtA precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Efflux pump membrane transporter BepE. | 0.881 |
mdtA_4 | cusS_4 | SRM1_04708 | SRM1_04711 | Multidrug resistance protein MdtA precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Sensor kinase CusS; Member of a two-component regulatory system. | 0.807 |
mdtA_4 | czcR_5 | SRM1_04708 | SRM1_04710 | Multidrug resistance protein MdtA precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Transcriptional activator protein CzcR. | 0.800 |
mdtA_4 | macB | SRM1_04708 | SRM1_01945 | Multidrug resistance protein MdtA precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Macrolide export ATP-binding/permease protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. | 0.912 |
mdtA_4 | mdtB_1 | SRM1_04708 | SRM1_02436 | Multidrug resistance protein MdtA precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Multidrug resistance protein MdtB; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.888 |
mdtA_4 | mdtB_2 | SRM1_04708 | SRM1_04709 | Multidrug resistance protein MdtA precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. | Multidrug resistance protein MdtB; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. | 0.972 |