| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| hemA | moeB | SRM1_04800 | SRM1_04797 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Molybdopterin-synthase adenylyltransferase. | 0.904 |
| hemA | murI | SRM1_04800 | SRM1_04796 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.898 |
| hemA | prmC | SRM1_04800 | SRM1_04798 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Release factor glutamine methyltransferase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | 0.906 |
| iscS_1 | iscS_2 | SRM1_03813 | SRM1_04656 | Cysteine desulfurase. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.955 |
| iscS_1 | moaD | SRM1_03813 | SRM1_01007 | Cysteine desulfurase. | Molybdopterin synthase sulfur carrier subunit. | 0.514 |
| iscS_1 | moaE | SRM1_03813 | SRM1_01008 | Cysteine desulfurase. | Molybdopterin synthase catalytic subunit. | 0.426 |
| iscS_1 | moeB | SRM1_03813 | SRM1_04797 | Cysteine desulfurase. | Molybdopterin-synthase adenylyltransferase. | 0.982 |
| iscS_2 | iscS_1 | SRM1_04656 | SRM1_03813 | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | Cysteine desulfurase. | 0.955 |
| iscS_2 | moaD | SRM1_04656 | SRM1_01007 | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | Molybdopterin synthase sulfur carrier subunit. | 0.514 |
| iscS_2 | moaE | SRM1_04656 | SRM1_01008 | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | Molybdopterin synthase catalytic subunit. | 0.426 |
| iscS_2 | moeB | SRM1_04656 | SRM1_04797 | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | Molybdopterin-synthase adenylyltransferase. | 0.982 |
| moaD | iscS_1 | SRM1_01007 | SRM1_03813 | Molybdopterin synthase sulfur carrier subunit. | Cysteine desulfurase. | 0.514 |
| moaD | iscS_2 | SRM1_01007 | SRM1_04656 | Molybdopterin synthase sulfur carrier subunit. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.514 |
| moaD | moaE | SRM1_01007 | SRM1_01008 | Molybdopterin synthase sulfur carrier subunit. | Molybdopterin synthase catalytic subunit. | 0.999 |
| moaD | moeA | SRM1_01007 | SRM1_03859 | Molybdopterin synthase sulfur carrier subunit. | Molybdopterin molybdenumtransferase; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. | 0.899 |
| moaD | moeB | SRM1_01007 | SRM1_04797 | Molybdopterin synthase sulfur carrier subunit. | Molybdopterin-synthase adenylyltransferase. | 0.996 |
| moaD | thiG | SRM1_01007 | SRM1_05425 | Molybdopterin synthase sulfur carrier subunit. | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. | 0.637 |
| moaD | thiS | SRM1_01007 | SRM1_05426 | Molybdopterin synthase sulfur carrier subunit. | Sulfur carrier protein ThiS. | 0.519 |
| moaE | iscS_1 | SRM1_01008 | SRM1_03813 | Molybdopterin synthase catalytic subunit. | Cysteine desulfurase. | 0.426 |
| moaE | iscS_2 | SRM1_01008 | SRM1_04656 | Molybdopterin synthase catalytic subunit. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.426 |