| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| dxs | ispA | SRM1_05099 | SRM1_05098 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.977 |
| dxs | ispB | SRM1_05099 | SRM1_04912 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.447 |
| dxs | ispH | SRM1_05099 | SRM1_04899 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.927 |
| dxs | ispU | SRM1_05099 | SRM1_01133 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific); Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.491 |
| dxs | xseB | SRM1_05099 | SRM1_05097 | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Exodeoxyribonuclease 7 small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. | 0.866 |
| etfA_1 | ispA | SRM1_04062 | SRM1_05098 | Electron transfer flavoprotein subunit alpha. | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.635 |
| etfA_1 | ispB | SRM1_04062 | SRM1_04912 | Electron transfer flavoprotein subunit alpha. | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.635 |
| ispA | dxs | SRM1_05098 | SRM1_05099 | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.977 |
| ispA | etfA_1 | SRM1_05098 | SRM1_04062 | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Electron transfer flavoprotein subunit alpha. | 0.635 |
| ispA | ispB | SRM1_05098 | SRM1_04912 | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.983 |
| ispA | ispH | SRM1_05098 | SRM1_04899 | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.978 |
| ispA | ispU | SRM1_05098 | SRM1_01133 | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific); Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.994 |
| ispA | tadA | SRM1_05098 | SRM1_04622 | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | tRNA-specific adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.698 |
| ispA | ubiA | SRM1_05098 | SRM1_05752 | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.718 |
| ispA | xseA | SRM1_05098 | SRM1_04636 | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Exodeoxyribonuclease 7 large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. | 0.677 |
| ispA | xseB | SRM1_05098 | SRM1_05097 | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Exodeoxyribonuclease 7 small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. | 0.976 |
| ispA | yfcD | SRM1_05098 | SRM1_00691 | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Putative Nudix hydrolase YfcD. | 0.945 |
| ispB | dxs | SRM1_04912 | SRM1_05099 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.447 |
| ispB | etfA_1 | SRM1_04912 | SRM1_04062 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Electron transfer flavoprotein subunit alpha. | 0.635 |
| ispB | ispA | SRM1_04912 | SRM1_05098 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.983 |