node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ahcY | cysK | SRM1_05374 | SRM1_01402 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.862 |
ahcY | guaA_2 | SRM1_05374 | SRM1_04632 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.578 |
ahcY | guaB | SRM1_05374 | SRM1_04633 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.595 |
ahcY | hom | SRM1_05374 | SRM1_01082 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Homoserine dehydrogenase. | 0.829 |
ahcY | metE | SRM1_05374 | SRM1_04478 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.890 |
ahcY | metF | SRM1_05374 | SRM1_05375 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.709 |
ahcY | metH | SRM1_05374 | SRM1_02950 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.831 |
ahcY | metK | SRM1_05374 | SRM1_05360 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.844 |
ahcY | metZ | SRM1_05374 | SRM1_01998 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.933 |
ahcY | ribD | SRM1_05374 | SRM1_05111 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.576 |
cysK | ahcY | SRM1_01402 | SRM1_05374 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.862 |
cysK | guaA_2 | SRM1_01402 | SRM1_04632 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.424 |
cysK | hom | SRM1_01402 | SRM1_01082 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Homoserine dehydrogenase. | 0.455 |
cysK | metH | SRM1_01402 | SRM1_02950 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.472 |
cysK | metZ | SRM1_01402 | SRM1_01998 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.965 |
guaA_2 | ahcY | SRM1_04632 | SRM1_05374 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.578 |
guaA_2 | cysK | SRM1_04632 | SRM1_01402 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.424 |
guaA_2 | guaB | SRM1_04632 | SRM1_04633 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA_2 | hom | SRM1_04632 | SRM1_01082 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Homoserine dehydrogenase. | 0.528 |
guaA_2 | metH | SRM1_04632 | SRM1_02950 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.677 |