STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hypDHydrogenase expression/formation protein HypD; Belongs to the HypD family. (370 aa)    
Predicted Functional Partners:
hypE
Hydrogenase expression/formation protein HypE.
 
 
 0.999
hypC
Hydrogenase expression/formation protein HypC.
 
 
 0.999
hypB
Hydrogenase expression/formation protein HypB.
 
  
 0.988
hypF
Hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
  
 0.972
hypA
Hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.949
Lbru_0497
Coenzyme F420-reducing hydrogenase, alpha subunit.
 
   
 0.865
vhtD
Hydrogenase expression/formation protein.
     
 0.808
Lbru_0498
Sulfhydrogenase subunit delta.
 
   
 0.799
Lbru_0500
Hydrogenase subunit.
     
 0.776
hydG-2
Hydrogenase/sulfur reductase subunit gamma.
       0.726
Your Current Organism:
Legionella brunensis
NCBI taxonomy Id: 29422
Other names: ATCC 43878, CCUG 31114, CIP 103874, DSM 19236, L. brunensis, NCTC 12240, strain 441-1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.