STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cbpACurved DNA binding protein DnaJ. (309 aa)    
Predicted Functional Partners:
dnaK
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 0.988
Lbru_1068
Putative chaperone-modulator protein CbpM.
 
 
 0.986
grpE
Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]
 
 
 0.932
htpG
Class III heat-shock protein HtpG(molecular chaperone); Molecular chaperone. Has ATPase activity.
  
 0.891
htpB
Molecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.821
legA
Ankyrin-repeat containing protein, substrate of the Dot/Icm secretion system.
    
 
 0.811
Lbru_1742
HAD-superfamily phosphatase.
   
 
 0.806
Lbru_1276
Acetyltransferase.
  
 
 0.795
Lbru_1462
Polyketide synthase.
   
 
 0.782
osmY
Osmotically inducible protein Y- like protein.
       0.732
Your Current Organism:
Legionella brunensis
NCBI taxonomy Id: 29422
Other names: ATCC 43878, CCUG 31114, CIP 103874, DSM 19236, L. brunensis, NCTC 12240, strain 441-1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.