node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDG84608.1 | SDH55248.1 | SAMN05216588_101165 | SAMN05216588_105211 | Cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | 0.866 |
SDG84608.1 | SDI36359.1 | SAMN05216588_101165 | SAMN05216588_115105 | Cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | DNA polymerase V; Belongs to the peptidase S24 family. | 0.647 |
SDG84608.1 | lexA | SAMN05216588_101165 | SAMN05216588_101164 | Cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.914 |
SDG84608.1 | recA | SAMN05216588_101165 | SAMN05216588_10788 | Cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.615 |
SDH55248.1 | SDG84608.1 | SAMN05216588_105211 | SAMN05216588_101165 | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | Cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | 0.866 |
SDH55248.1 | SDI36359.1 | SAMN05216588_105211 | SAMN05216588_115105 | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | DNA polymerase V; Belongs to the peptidase S24 family. | 0.689 |
SDH55248.1 | grpE | SAMN05216588_105211 | SAMN05216588_105210 | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.665 |
SDH55248.1 | lexA | SAMN05216588_105211 | SAMN05216588_101164 | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.692 |
SDH55248.1 | mfd | SAMN05216588_105211 | SAMN05216588_101161 | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | Transcription-repair coupling factor (superfamily II helicase); Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.675 |
SDH55248.1 | pheT | SAMN05216588_105211 | SAMN05216588_10458 | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.662 |
SDH55248.1 | radA | SAMN05216588_105211 | SAMN05216588_108220 | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | DNA replication and repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.650 |
SDH55248.1 | recA | SAMN05216588_105211 | SAMN05216588_10788 | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.890 |
SDH55248.1 | uvrC | SAMN05216588_105211 | SAMN05216588_102189 | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.666 |
SDH55248.1 | xseA | SAMN05216588_105211 | SAMN05216588_107260 | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | Exodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. | 0.626 |
SDI36359.1 | SDG84608.1 | SAMN05216588_115105 | SAMN05216588_101165 | DNA polymerase V; Belongs to the peptidase S24 family. | Cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | 0.647 |
SDI36359.1 | SDH55248.1 | SAMN05216588_115105 | SAMN05216588_105211 | DNA polymerase V; Belongs to the peptidase S24 family. | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | 0.689 |
SDI36359.1 | recA | SAMN05216588_115105 | SAMN05216588_10788 | DNA polymerase V; Belongs to the peptidase S24 family. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.973 |
grpE | SDH55248.1 | SAMN05216588_105210 | SAMN05216588_105211 | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | 0.665 |
lexA | SDG84608.1 | SAMN05216588_101164 | SAMN05216588_101165 | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | Cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | 0.914 |
lexA | SDH55248.1 | SAMN05216588_101164 | SAMN05216588_105211 | Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | DNA repair protein RecN (Recombination protein N); May be involved in recombinational repair of damaged DNA. | 0.692 |