node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDH96280.1 | SDI27569.1 | SAMN05216588_109136 | SAMN05216588_11437 | Homoserine dehydrogenase. | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 0.989 |
SDH96280.1 | SDI79979.1 | SAMN05216588_109136 | SAMN05216588_1256 | Homoserine dehydrogenase. | Acetolactate synthase, small subunit. | 0.942 |
SDH96280.1 | SDI80012.1 | SAMN05216588_109136 | SAMN05216588_1257 | Homoserine dehydrogenase. | Acetolactate synthase, large subunit. | 0.990 |
SDH96280.1 | SDI81791.1 | SAMN05216588_109136 | SAMN05216588_12563 | Homoserine dehydrogenase. | Branched-chain amino acid aminotransferase. | 0.954 |
SDH96280.1 | ilvC | SAMN05216588_109136 | SAMN05216588_1254 | Homoserine dehydrogenase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.985 |
SDH96280.1 | ilvD | SAMN05216588_109136 | SAMN05216588_12147 | Homoserine dehydrogenase. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.889 |
SDH96280.1 | leuA | SAMN05216588_109136 | SAMN05216588_107252 | Homoserine dehydrogenase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.931 |
SDH96280.1 | leuB | SAMN05216588_109136 | SAMN05216588_101408 | Homoserine dehydrogenase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.977 |
SDH96280.1 | leuC | SAMN05216588_109136 | SAMN05216588_101411 | Homoserine dehydrogenase. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.967 |
SDH96280.1 | leuD | SAMN05216588_109136 | SAMN05216588_101410 | Homoserine dehydrogenase. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.974 |
SDI27569.1 | SDH96280.1 | SAMN05216588_11437 | SAMN05216588_109136 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Homoserine dehydrogenase. | 0.989 |
SDI27569.1 | SDI79979.1 | SAMN05216588_11437 | SAMN05216588_1256 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit. | 0.989 |
SDI27569.1 | SDI81791.1 | SAMN05216588_11437 | SAMN05216588_12563 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Branched-chain amino acid aminotransferase. | 0.598 |
SDI27569.1 | ilvC | SAMN05216588_11437 | SAMN05216588_1254 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.957 |
SDI27569.1 | ilvD | SAMN05216588_11437 | SAMN05216588_12147 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.882 |
SDI27569.1 | leuA | SAMN05216588_11437 | SAMN05216588_107252 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.713 |
SDI27569.1 | leuB | SAMN05216588_11437 | SAMN05216588_101408 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.893 |
SDI27569.1 | leuC | SAMN05216588_11437 | SAMN05216588_101411 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.843 |
SDI27569.1 | leuD | SAMN05216588_11437 | SAMN05216588_101410 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.858 |
SDI79979.1 | SDH96280.1 | SAMN05216588_1256 | SAMN05216588_109136 | Acetolactate synthase, small subunit. | Homoserine dehydrogenase. | 0.942 |