Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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cbiACobyrinic acid a,c-diamide synthase CbiA; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. (504 aa)    
Predicted Functional Partners:
cbiT
precorrin-6Y C5,15-methyltransferase (decarboxylating) CbiET; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
  
 0.995
YLM1_0239
Precorrin-6x reductase CbiJ.
 
  
 0.994
YLM1_0242
precorrin-8X methylmutase CbiC.
 
 0.982
YLM1_1795
Magnesium chelatase subunit.
 
 
 0.957
YLM1_0241
Cobyrinic acid a,c-diamide synthase CbiA.
  
  
 
0.911
cobQ
Cobyric acid synthase CbiP; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
  
 0.902
cobD
Cobalamin biosynthesis protein CbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
  
 0.883
YLM1_0234
Precorrin-2 C20-methyltransferase CbiL; Belongs to the precorrin methyltransferase family.
  
 0.835
YLM1_0236
Precorrin-4 C11-methyltransferase CbiF.
 
  
 0.753
YLM1_0237
Cobalamin biosynthesis protein CbiG.
 
  
 0.751
Your Current Organism:
Methanobrevibacter olleyae
NCBI taxonomy Id: 294671
Other names: DSM 16632, M. olleyae, Methanobrevibacter olleyae Rea et al. 2007, Methanobrevibacter sp. KM1H5-1P, OCM 841, strain KM1H5-1P
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