STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spo0ASporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. (259 aa)    
Predicted Functional Partners:
spoIVB
spore_IV_B: stage IV sporulation protein B; [M] COG0750 Predicted membrane-associated Zn-dependent proteases 1.
   
 0.948
spo0F
Sporulation initiation phosphotransferase F; [T] COG0784 FOG: CheY-like receiver.
  
 
0.919
ANB60141.1
Sensor kinase SpoOB-type, alpha-helical domain protein.
     
 0.918
kinE
Sporulation kinase E; [T] COG0642 Signal transduction histidine kinase.
     
 0.916
sigG
RNA polymerase sigma-G factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
   
 0.846
spoVT
spore_V_T: stage V sporulation protein T; [K] COG2002 Regulators of stationary/sporulation gene expression.
  
   
 0.804
sigE
RNA polymerase sigma-E factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
   
 0.801
spoIVA
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
   
 0.800
spoIIAB
Anti-sigma F factor; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
 
  
 0.799
spoIIID
spore_III_D: sporulation transcriptional regulator SpoIIID.
  
   
 0.797
Your Current Organism:
Anoxybacillus amylolyticus
NCBI taxonomy Id: 294699
Other names: A. amylolyticus, ATCC BAA-872, Anoxybacillus amylolyticus Poli et al. 2006, CIP 108338, DSM 15939, strain MR3C
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