STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NBP35Cytosolic Fe-S cluster assembly factor NBP35; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NB [...] (342 aa)    
Predicted Functional Partners:
DRE2
Fe-S cluster assembly protein DRE2; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by [...]
   
 0.840
CFD1
Cytosolic Fe-S cluster assembly factor CFD1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD [...]
  
0.803
CTRG_03246
Fe_hyd_lg_C domain-containing protein; Belongs to the NARF family.
   
 0.748
CTRG_02766
Transporter ATM1, mitochondrial.
    
 0.692
CTRG_03245
NADH-ubiquinone oxidoreductase 23 kDa subunit, mitochondrial.
  
 
 0.677
TAH18
NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of DRE2. Positively controls H(2)O(2)-induced cell death; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
    
 0.659
CTRG_02172
NADH-ubiquinone oxidoreductase 30.4 kDa subunit, mitochondrial; Belongs to the complex I 30 kDa subunit family.
     
 0.655
CTRG_05173
NADH-ubiquinone oxidoreductase 49 kDa subunit, mitochondrial; Belongs to the complex I 49 kDa subunit family.
     
 0.655
CTRG_01110
NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial.
     
 0.619
CTRG_04173
Glutaredoxin; Belongs to the glutaredoxin family. Monothiol subfamily.
     
 0.618
Your Current Organism:
Candida tropicalis
NCBI taxonomy Id: 294747
Other names: C. tropicalis MYA-3404, Candida tropicalis MYA-3404, Candida tropicalis T1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.