node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CH64_2401 | apt | CH64_2401 | CH64_3613 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.901 |
CH64_2401 | gmk | CH64_2401 | CH64_2639 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.900 |
CH64_2401 | gpt | CH64_2401 | CH64_3519 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.901 |
CH64_2401 | guaA | CH64_2401 | CH64_1453 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.915 |
CH64_2401 | guaB | CH64_2401 | CH64_1454 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.906 |
CH64_2401 | guaC | CH64_2401 | CH64_3303 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.906 |
CH64_2401 | hpt | CH64_2401 | CH64_3334 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | HGPRTase: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.900 |
CH64_2401 | purA | CH64_2401 | CH64_3011 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.904 |
CH64_2401 | purH | CH64_2401 | CH64_2900 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.904 |
CH64_2401 | surE | CH64_2401 | CH64_3386 | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | 5'/3'-nucleotidase SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. | 0.916 |
apt | CH64_2401 | CH64_3613 | CH64_2401 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | 0.901 |
apt | gmk | CH64_3613 | CH64_2639 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.962 |
apt | gpt | CH64_3613 | CH64_3519 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.941 |
apt | guaA | CH64_3613 | CH64_1453 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.991 |
apt | guaC | CH64_3613 | CH64_3303 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.930 |
apt | hpt | CH64_3613 | CH64_3334 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | HGPRTase: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.931 |
apt | purA | CH64_3613 | CH64_3011 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.630 |
apt | purH | CH64_3613 | CH64_2900 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.967 |
apt | surE | CH64_3613 | CH64_3386 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 5'/3'-nucleotidase SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. | 0.921 |
gmk | CH64_2401 | CH64_2639 | CH64_2401 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | HAD-SF-IA-v3: HAD hydrolase, IA, variant 3 family protein. | 0.900 |