node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CH64_1934 | bioR | CH64_1934 | CH64_2869 | Isochorismatase family protein. | Biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.435 |
CH64_1934 | gpsA | CH64_1934 | CH64_2668 | Isochorismatase family protein. | Ketopantoate reductase PanE/ApbA family protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.404 |
CH64_1934 | guaA | CH64_1934 | CH64_1453 | Isochorismatase family protein. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.424 |
CH64_1934 | nadE | CH64_1934 | CH64_1494 | Isochorismatase family protein. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.473 |
CH64_1934 | nadR | CH64_1934 | CH64_3205 | Isochorismatase family protein. | Trifunctional NAD biosynthesis/regulator protein NadR. | 0.458 |
CH64_1934 | pgm | CH64_1934 | CH64_3760 | Isochorismatase family protein. | Pgm: phosphoglucomutase, alpha-D-glucose phosphate-specific. | 0.440 |
CH64_1934 | yecD | CH64_1934 | CH64_398 | Isochorismatase family protein. | Isochorismatase family protein. | 0.474 |
bioR | CH64_1934 | CH64_2869 | CH64_1934 | Biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Isochorismatase family protein. | 0.435 |
bioR | guaA | CH64_2869 | CH64_1453 | Biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.576 |
bioR | nadE | CH64_2869 | CH64_1494 | Biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.560 |
bioR | nadR | CH64_2869 | CH64_3205 | Biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Trifunctional NAD biosynthesis/regulator protein NadR. | 0.540 |
bioR | yecD | CH64_2869 | CH64_398 | Biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Isochorismatase family protein. | 0.435 |
gpsA | CH64_1934 | CH64_2668 | CH64_1934 | Ketopantoate reductase PanE/ApbA family protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | Isochorismatase family protein. | 0.404 |
gpsA | pgm | CH64_2668 | CH64_3760 | Ketopantoate reductase PanE/ApbA family protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | Pgm: phosphoglucomutase, alpha-D-glucose phosphate-specific. | 0.556 |
gpsA | yecD | CH64_2668 | CH64_398 | Ketopantoate reductase PanE/ApbA family protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | Isochorismatase family protein. | 0.404 |
guaA | CH64_1934 | CH64_1453 | CH64_1934 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Isochorismatase family protein. | 0.424 |
guaA | bioR | CH64_1453 | CH64_2869 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.576 |
guaA | nadE | CH64_1453 | CH64_1494 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.587 |
guaA | nadR | CH64_1453 | CH64_3205 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Trifunctional NAD biosynthesis/regulator protein NadR. | 0.439 |
guaA | yecD | CH64_1453 | CH64_398 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Isochorismatase family protein. | 0.424 |