| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CH64_297 | bioR | CH64_297 | CH64_2869 | Thiolase, N-terminal domain protein. | Biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.617 |
| CH64_297 | qor2_2 | CH64_297 | CH64_296 | Thiolase, N-terminal domain protein. | Zinc-binding dehydrogenase family protein. | 0.999 |
| CH64_297 | rrmA | CH64_297 | CH64_855 | Thiolase, N-terminal domain protein. | ubiE/COQ5 methyltransferase family protein. | 0.441 |
| bioR | CH64_297 | CH64_2869 | CH64_297 | Biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Thiolase, N-terminal domain protein. | 0.617 |
| bioR | qor2_2 | CH64_2869 | CH64_296 | Biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Zinc-binding dehydrogenase family protein. | 0.552 |
| bioR | rrmA | CH64_2869 | CH64_855 | Biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | ubiE/COQ5 methyltransferase family protein. | 0.417 |
| dapE | rrmA | CH64_1399 | CH64_855 | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | ubiE/COQ5 methyltransferase family protein. | 0.751 |
| qor2_2 | CH64_297 | CH64_296 | CH64_297 | Zinc-binding dehydrogenase family protein. | Thiolase, N-terminal domain protein. | 0.999 |
| qor2_2 | bioR | CH64_296 | CH64_2869 | Zinc-binding dehydrogenase family protein. | Biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.552 |
| qor2_2 | rrmA | CH64_296 | CH64_855 | Zinc-binding dehydrogenase family protein. | ubiE/COQ5 methyltransferase family protein. | 0.441 |
| rrmA | CH64_297 | CH64_855 | CH64_297 | ubiE/COQ5 methyltransferase family protein. | Thiolase, N-terminal domain protein. | 0.441 |
| rrmA | bioR | CH64_855 | CH64_2869 | ubiE/COQ5 methyltransferase family protein. | Biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.417 |
| rrmA | dapE | CH64_855 | CH64_1399 | ubiE/COQ5 methyltransferase family protein. | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. | 0.751 |
| rrmA | qor2_2 | CH64_855 | CH64_296 | ubiE/COQ5 methyltransferase family protein. | Zinc-binding dehydrogenase family protein. | 0.441 |
| rrmA | yfiH_1 | CH64_855 | CH64_856 | ubiE/COQ5 methyltransferase family protein. | Multi-copper polyphenol oxidoreductase laccase family protein; Belongs to the multicopper oxidase YfiH/RL5 family. | 0.496 |
| yfiH_1 | rrmA | CH64_856 | CH64_855 | Multi-copper polyphenol oxidoreductase laccase family protein; Belongs to the multicopper oxidase YfiH/RL5 family. | ubiE/COQ5 methyltransferase family protein. | 0.496 |