| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ccmE | hydA | UGYR_05125 | UGYR_00635 | Cytochrome C biogenesis protein CcmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. | Carbamoyl phosphate phosphatase; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | 0.561 |
| hoxN | hycI | UGYR_00630 | UGYR_00650 | Nickel transporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NiCoT transporter (TC 2.A.52) family. | Hydrogenase 3 maturation protease; Involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.443 |
| hoxN | hydA | UGYR_00630 | UGYR_00635 | Nickel transporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NiCoT transporter (TC 2.A.52) family. | Carbamoyl phosphate phosphatase; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | 0.896 |
| hoxN | hydN | UGYR_00630 | UGYR_00645 | Nickel transporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NiCoT transporter (TC 2.A.52) family. | Effector protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.500 |
| hoxN | hypA | UGYR_00630 | UGYR_00695 | Nickel transporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NiCoT transporter (TC 2.A.52) family. | Hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | 0.489 |
| hoxN | hypB | UGYR_00630 | UGYR_00700 | Nickel transporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NiCoT transporter (TC 2.A.52) family. | Hydrogenase nickel incorporation protein HypB; GTP hydrolase involved in nickel liganding into hydrogenases; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.455 |
| hycE | hycI | UGYR_00670 | UGYR_00650 | Hydrogenase 3 large subunit; Formate hydrogenlyase subunit 5; HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hydrogenase 3 maturation protease; Involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.952 |
| hycE | hydA | UGYR_00670 | UGYR_00635 | Hydrogenase 3 large subunit; Formate hydrogenlyase subunit 5; HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. | Carbamoyl phosphate phosphatase; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | 0.777 |
| hycE | hydN | UGYR_00670 | UGYR_00645 | Hydrogenase 3 large subunit; Formate hydrogenlyase subunit 5; HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. | Effector protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.967 |
| hycE | hypA | UGYR_00670 | UGYR_00695 | Hydrogenase 3 large subunit; Formate hydrogenlyase subunit 5; HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | 0.898 |
| hycE | hypB | UGYR_00670 | UGYR_00700 | Hydrogenase 3 large subunit; Formate hydrogenlyase subunit 5; HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hydrogenase nickel incorporation protein HypB; GTP hydrolase involved in nickel liganding into hydrogenases; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.962 |
| hycE | hypC | UGYR_00670 | UGYR_00705 | Hydrogenase 3 large subunit; Formate hydrogenlyase subunit 5; HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hydrogenase assembly chaperone; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.791 |
| hycE | hypD | UGYR_00670 | UGYR_00710 | Hydrogenase 3 large subunit; Formate hydrogenlyase subunit 5; HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hydrogenase isoenzymes formation protein HypD; Necessary for the synthesis of all three hydrogenase isoenzymes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HypD family. | 0.672 |
| hycE | hypE | UGYR_00670 | UGYR_00715 | Hydrogenase 3 large subunit; Formate hydrogenlyase subunit 5; HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. | Carbamoyl dehydratase HypE; Hydrogenase isoenzymes formation protein; involved in the formation of the cyanate group of the large subunit of the hydrogenase; catalyzes the formation of thiocyanate from thiocarbamate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.683 |
| hycI | hoxN | UGYR_00650 | UGYR_00630 | Hydrogenase 3 maturation protease; Involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Nickel transporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NiCoT transporter (TC 2.A.52) family. | 0.443 |
| hycI | hycE | UGYR_00650 | UGYR_00670 | Hydrogenase 3 maturation protease; Involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hydrogenase 3 large subunit; Formate hydrogenlyase subunit 5; HycBCDEFG is part of the formate hydrogenlyase system which is involved in the cleaving of formate to dihydrogen and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.952 |
| hycI | hydA | UGYR_00650 | UGYR_00635 | Hydrogenase 3 maturation protease; Involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Carbamoyl phosphate phosphatase; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. | 0.568 |
| hycI | hydN | UGYR_00650 | UGYR_00645 | Hydrogenase 3 maturation protease; Involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Effector protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.905 |
| hycI | hypA | UGYR_00650 | UGYR_00695 | Hydrogenase 3 maturation protease; Involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hydrogenase nickel incorporation protein; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | 0.553 |
| hycI | hypD | UGYR_00650 | UGYR_00710 | Hydrogenase 3 maturation protease; Involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hydrogenase isoenzymes formation protein HypD; Necessary for the synthesis of all three hydrogenase isoenzymes; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HypD family. | 0.429 |
