| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cyaA | ratA | UGYR_09305 | UGYR_06185 | Adenylate cyclase; Catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the adenylyl cyclase class-1 family. | Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.509 |
| pufX | ratA | UGYR_04635 | UGYR_06185 | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.593 |
| pufX | ubiA | UGYR_04635 | UGYR_08450 | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 4-hydroxybenzoate polyprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.841 |
| pufX | ubiB | UGYR_04635 | UGYR_08950 | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | Ubiquinone biosynthesis protein UbiB; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. | 0.693 |
| pufX | ubiF_2 | UGYR_04635 | UGYR_07110 | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.992 |
| ratA | cyaA | UGYR_06185 | UGYR_09305 | Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Adenylate cyclase; Catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the adenylyl cyclase class-1 family. | 0.509 |
| ratA | pufX | UGYR_06185 | UGYR_04635 | Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.593 |
| ratA | ratB | UGYR_06185 | UGYR_06180 | Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0125 (RnfH) family. | 0.897 |
| ratA | smpB | UGYR_06185 | UGYR_06190 | Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] | 0.572 |
| ratA | sspA | UGYR_06185 | UGYR_08015 | Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Stringent starvation protein A; Transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GST superfamily. | 0.588 |
| ratA | ubiA | UGYR_06185 | UGYR_08450 | Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 4-hydroxybenzoate polyprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.519 |
| ratA | ubiB | UGYR_06185 | UGYR_08950 | Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ubiquinone biosynthesis protein UbiB; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. | 0.478 |
| ratA | ubiF_2 | UGYR_06185 | UGYR_07110 | Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.535 |
| ratB | ratA | UGYR_06180 | UGYR_06185 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0125 (RnfH) family. | Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.897 |
| ratB | smpB | UGYR_06180 | UGYR_06190 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0125 (RnfH) family. | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] | 0.567 |
| smpB | ratA | UGYR_06190 | UGYR_06185 | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] | Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.572 |
| smpB | ratB | UGYR_06190 | UGYR_06180 | SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0125 (RnfH) family. | 0.567 |
| sspA | ratA | UGYR_08015 | UGYR_06185 | Stringent starvation protein A; Transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GST superfamily. | Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.588 |
| sspA | ubiF_2 | UGYR_08015 | UGYR_07110 | Stringent starvation protein A; Transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GST superfamily. | Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.504 |
| ubiA | pufX | UGYR_08450 | UGYR_04635 | 4-hydroxybenzoate polyprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. | 0.841 |