node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKA39293.1 | ligT | UGYR_13405 | UGYR_13400 | Similar in sequence to the ATP-dependent RNA helicase HrpA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.507 |
AKA39293.1 | mrcB | UGYR_13405 | UGYR_13410 | Similar in sequence to the ATP-dependent RNA helicase HrpA; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional glycosyl transferase/transpeptidase; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | 0.559 |
AKA39293.1 | sfsA | UGYR_13405 | UGYR_13395 | Similar in sequence to the ATP-dependent RNA helicase HrpA; Derived by automated computational analysis using gene prediction method: Protein Homology. | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SfsA family. | 0.514 |
ampM | sfsA | UGYR_06710 | UGYR_13395 | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SfsA family. | 0.719 |
ampM | yadB | UGYR_06710 | UGYR_13385 | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | glutamyl-Q tRNA(Asp) ligase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. | 0.889 |
dksA | ligT | UGYR_13390 | UGYR_13400 | RNA polymerase-binding transcription factor; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.447 |
dksA | sfsA | UGYR_13390 | UGYR_13395 | RNA polymerase-binding transcription factor; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SfsA family. | 0.703 |
dksA | yadB | UGYR_13390 | UGYR_13385 | RNA polymerase-binding transcription factor; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | glutamyl-Q tRNA(Asp) ligase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. | 0.725 |
hda | sfsA | UGYR_05560 | UGYR_13395 | DNA replication initiation factor; Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA; Belongs to the DnaA family. HdA subfamily. | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SfsA family. | 0.456 |
hda | yadB | UGYR_05560 | UGYR_13385 | DNA replication initiation factor; Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA; Belongs to the DnaA family. HdA subfamily. | glutamyl-Q tRNA(Asp) ligase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. | 0.477 |
ligT | AKA39293.1 | UGYR_13400 | UGYR_13405 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Similar in sequence to the ATP-dependent RNA helicase HrpA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.507 |
ligT | dksA | UGYR_13400 | UGYR_13390 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | RNA polymerase-binding transcription factor; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | 0.447 |
ligT | sfsA | UGYR_13400 | UGYR_13395 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SfsA family. | 0.839 |
ligT | yadB | UGYR_13400 | UGYR_13385 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | glutamyl-Q tRNA(Asp) ligase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. | 0.471 |
mrcB | AKA39293.1 | UGYR_13410 | UGYR_13405 | Bifunctional glycosyl transferase/transpeptidase; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | Similar in sequence to the ATP-dependent RNA helicase HrpA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.559 |
mrcB | sfsA | UGYR_13410 | UGYR_13395 | Bifunctional glycosyl transferase/transpeptidase; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SfsA family. | 0.419 |
mutY | sfsA | UGYR_07315 | UGYR_13395 | Adenine glycosylase; Adenine glycosylase active on G-A mispairs. | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SfsA family. | 0.928 |
proA | sfsA | UGYR_14235 | UGYR_13395 | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SfsA family. | 0.454 |
sfsA | AKA39293.1 | UGYR_13395 | UGYR_13405 | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SfsA family. | Similar in sequence to the ATP-dependent RNA helicase HrpA; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.514 |
sfsA | ampM | UGYR_13395 | UGYR_06710 | Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SfsA family. | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.719 |