STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
macA_1Confers macrolide resistance via active drug efflux; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (371 aa)    
Predicted Functional Partners:
macB
Macrolide transporter; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
 
 0.999
acrB
Multidrug transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
  0.822
acrD
Multidrug transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
 0.817
tolC_2
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.630
AKA38073.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
  
 0.616
pF
Peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.585
mdtC
Multidrug transporter; Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
 
  0.561
yegO
Multidrug transporter; Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily.
 
  0.561
mexB
Multidrug transporter AcrB; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
  
  0.561
lolD
Lipoprotein ABC transporter ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner.
 
 
 0.536
Your Current Organism:
Yersinia ruckeri
NCBI taxonomy Id: 29486
Other names: ATCC 29473, CCM 6093, CCUG 14190, CDC 2396-61, CIP 82.80, DSM 18506, JCM 15110, JCM 2429, NCIB 2194, NCIMB 2194, NCTC 12986, Y. ruckeri
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