| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KMK93436.1 | KMK93483.1 | VL01_12555 | VL01_12815 | Peptidase M16; Derived by automated computational analysis using gene prediction method: Protein Homology. | NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.562 |
| KMK93483.1 | KMK93436.1 | VL01_12815 | VL01_12555 | NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Peptidase M16; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.562 |
| KMK93483.1 | KMK97104.1 | VL01_12815 | VL01_06420 | NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.637 |
| KMK93483.1 | KMK98607.1 | VL01_12815 | VL01_01885 | NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Peptidase M16; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.562 |
| KMK93483.1 | birA | VL01_12815 | VL01_13350 | NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.642 |
| KMK93483.1 | cpsB | VL01_12815 | VL01_02155 | NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Mannose-1-phosphate guanyltransferase; Capsular polysaccharide colanic acid biosynthesis protein; catalyzes the formation of GDP-mannose from GTP and alpha-D-mannose 1-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.661 |
| KMK93483.1 | dapF | VL01_12815 | VL01_06210 | NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.594 |
| KMK93483.1 | nadE | VL01_12815 | VL01_01725 | NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.700 |
| KMK93483.1 | pabB | VL01_12815 | VL01_12820 | NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Para-aminobenzoate synthase component 1; catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and L-glutamine; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.665 |
| KMK93483.1 | ribB-2 | VL01_12815 | VL01_11125 | NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.714 |
| KMK93483.1 | thiE | VL01_12815 | VL01_06375 | NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Phosphomethylpyrimidine kinase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.648 |
| KMK97104.1 | KMK93483.1 | VL01_06420 | VL01_12815 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.637 |
| KMK97104.1 | cpsB | VL01_06420 | VL01_02155 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Mannose-1-phosphate guanyltransferase; Capsular polysaccharide colanic acid biosynthesis protein; catalyzes the formation of GDP-mannose from GTP and alpha-D-mannose 1-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.614 |
| KMK97104.1 | dapF | VL01_06420 | VL01_06210 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.626 |
| KMK97104.1 | thiE | VL01_06420 | VL01_06375 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphomethylpyrimidine kinase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.671 |
| KMK98607.1 | KMK93483.1 | VL01_01885 | VL01_12815 | Peptidase M16; Derived by automated computational analysis using gene prediction method: Protein Homology. | NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.562 |
| birA | KMK93483.1 | VL01_13350 | VL01_12815 | biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.642 |
| birA | dapF | VL01_13350 | VL01_06210 | biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.628 |
| birA | nadE | VL01_13350 | VL01_01725 | biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.771 |
| birA | ribB-2 | VL01_13350 | VL01_11125 | biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.623 |
