Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KMK92023.13-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (184 aa)    
Predicted Functional Partners:
KMK92022.1
D-arabinose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.998
kdsA
2-dehydro-3-deoxyphosphooctonate aldolase; Catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the KdsA family.
  
 0.993
kdsB
3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
 
  
 0.988
KMK92026.1
Sugar ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.936
lptC
Hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.
  
  
 0.930
lptA
Sugar ABC transporter substrate-binding protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
  
  
 0.900
KMK92829.1
N-acetylneuraminate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.889
KMK92827.1
NeuA; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   0.787
KMK91046.1
3-deoxy-D-manno-octulosonic acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.
 
  
 0.777
KMK92027.1
RNA polymerase factor sigma-54; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.689
Your Current Organism:
Aeromonas enteropelogenes
NCBI taxonomy Id: 29489
Other names: A. enteropelogenes, ATCC 49657 [[Aeromonas trota]], ATCC 49803, Aeromonas sp. LK14, Aeromonas trota, Aeromonas tructi, CCUG 29544 [[Aeromonas trota]], CCUG 30367 [[Aeromonas trota]], CECT 4255 [[Aeromonas trota]], CECT 4487, CIP 103677 [[Aeromonas trota]], CIP 104434, DSM 6394, DSM 7312 [[Aeromonas trota]], JCM 8315 [[Aeromonas trota]], JCM 8355, LMG 12223 [[Aeromonas trota]], LMG 12646, LMG:12223 [[Aeromonas trota]], LMG:12646, strain AH2 [[Aeromonas trota]], strain J11
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