A4SJ14_AERS4 protein (Aeromonas salmonicida)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

A4SJ14_AERS4

Unannotated protein. (484 aa)

Predicted Functional Partners:

ravA

0.988

zapC

0.715

ilvM

0.663

A4SSG3_AERS4

0.649

A4SR40_AERS4

0.599

ompC

0.590

A4SPL5_AERS4

0.585

A4SNI4_AERS4

0.581

cyaA

0.577

A4SRF6_AERS4

0.574

Your Current Organism:

Aeromonas salmonicida

NCBI taxonomy Id: 29491
Other names: A. salmonicida subsp. salmonicida, Aeromonas salmonicida salmonicida, Aeromonas salmonicida subsp. salmonicida

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A4SJ14_AERS4	A4SNI4_AERS4	GCA_000820065_01767	GCA_000820065_01515	Unannotated protein.	Unannotated protein.	0.581
A4SJ14_AERS4	A4SPL5_AERS4	GCA_000820065_01767	GCA_000820065_01085	Unannotated protein.	Unannotated protein.	0.585
A4SJ14_AERS4	A4SR40_AERS4	GCA_000820065_01767	GCA_000820065_03782	Unannotated protein.	Unannotated protein.	0.599
A4SJ14_AERS4	A4SRF6_AERS4	GCA_000820065_01767	GCA_000820065_02056	Unannotated protein.	Unannotated protein.	0.574
A4SJ14_AERS4	A4SSG3_AERS4	GCA_000820065_01767	GCA_000820065_00888	Unannotated protein.	Unannotated protein.	0.649
A4SJ14_AERS4	cyaA	GCA_000820065_01767	GCA_000820065_00881	Unannotated protein.	Unannotated protein; Belongs to the adenylyl cyclase class-1 family.	0.577
A4SJ14_AERS4	ilvM	GCA_000820065_01767	GCA_000820065_04120	Unannotated protein.	Unannotated protein.	0.663
A4SJ14_AERS4	ompC	GCA_000820065_01767	GCA_000820065_04362	Unannotated protein.	Unannotated protein.	0.590
A4SJ14_AERS4	ravA	GCA_000820065_01767	GCA_000820065_01768	Unannotated protein.	Unannotated protein.	0.988
A4SJ14_AERS4	zapC	GCA_000820065_01767	GCA_000820065_03866	Unannotated protein.	Unannotated protein; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.	0.715
A4SNI4_AERS4	A4SJ14_AERS4	GCA_000820065_01515	GCA_000820065_01767	Unannotated protein.	Unannotated protein.	0.581
A4SNI4_AERS4	A4SPL5_AERS4	GCA_000820065_01515	GCA_000820065_01085	Unannotated protein.	Unannotated protein.	0.465
A4SNI4_AERS4	A4SR40_AERS4	GCA_000820065_01515	GCA_000820065_03782	Unannotated protein.	Unannotated protein.	0.573
A4SNI4_AERS4	A4SRF6_AERS4	GCA_000820065_01515	GCA_000820065_02056	Unannotated protein.	Unannotated protein.	0.664
A4SNI4_AERS4	ilvM	GCA_000820065_01515	GCA_000820065_04120	Unannotated protein.	Unannotated protein.	0.695
A4SNI4_AERS4	zapC	GCA_000820065_01515	GCA_000820065_03866	Unannotated protein.	Unannotated protein; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.	0.714
A4SPL5_AERS4	A4SJ14_AERS4	GCA_000820065_01085	GCA_000820065_01767	Unannotated protein.	Unannotated protein.	0.585
A4SPL5_AERS4	A4SNI4_AERS4	GCA_000820065_01085	GCA_000820065_01515	Unannotated protein.	Unannotated protein.	0.465
A4SPL5_AERS4	ilvM	GCA_000820065_01085	GCA_000820065_04120	Unannotated protein.	Unannotated protein.	0.767
A4SPL5_AERS4	zapC	GCA_000820065_01085	GCA_000820065_03866	Unannotated protein.	Unannotated protein; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.	0.552

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Network Stats

number of nodes:

10

number of edges:

19

average node degree:

3.8

avg. local clustering coefficient:

0.748

expected number of edges:

9

PPI enrichment p-value:

0.0043

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

9 of 133

1.68

3.48

1.37e-11

GO:0009059

Macromolecule biosynthetic process

10 of 385

1.26

1.97

3.16e-10

GO:0044271

Cellular nitrogen compound biosynthetic process

10 of 563

1.1

1.45

7.35e-09

GO:0044249

Cellular biosynthetic process

11 of 1106

0.85

0.92

7.54e-08

GO:1901576

Organic substance biosynthetic process

11 of 1134

0.84

0.9

9.01e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

9 of 60

2.03

5.47

9.12e-15

GO:0019843

rRNA binding

8 of 45

2.1

5.39

1.23e-13

GO:0003723

RNA binding

9 of 121

1.72

3.84

8.73e-13

GO:0000049

tRNA binding

3 of 22

1.98

1.6

0.00068

GO:1901363

Heterocyclic compound binding

10 of 2205

0.51

0.39

0.0034

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

9 of 64

2.0

5.49

2.69e-15

GO:0015935

Small ribosomal subunit

4 of 7

2.61

4.07

1.75e-08

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2498

Structural constituent of ribosome

9 of 70

1.96

4.99

6.48e-14

CL:2500

Structural constituent of ribosome

7 of 62

1.9

3.93

1.21e-10

CL:2613

Small ribosomal subunit, and Initiation factor

3 of 5

2.63

2.62

1.32e-05

CL:2506

Structural constituent of ribosome

4 of 47

1.78

1.93

5.50e-05

CL:2507

Structural constituent of ribosome

3 of 33

1.81

1.39

0.0014

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

9 of 68

1.97

5.33

4.43e-15

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0022627

Cytosolic small ribosomal subunit

4 of 7

2.61

3.66

1.20e-07

GOCC:0005840

Ribosome

6 of 46

1.97

3.48

1.01e-08

GOCC:0043229

Intracellular organelle

9 of 634

1.0

1.15

5.42e-07

GOCC:0005737

Cytoplasm

9 of 1865

0.53

0.42

0.0025

GOCC:0005622

Intracellular

11 of 2689

0.46

0.4

0.00026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0699

rRNA-binding

8 of 44

2.11

5.62

2.82e-14

KW-0689

Ribosomal protein

9 of 72

1.95

5.13

1.13e-14

KW-0820

tRNA-binding

2 of 13

2.04

1.08

0.0088

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