ppcE protein (Aeromonas salmonicida) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ppcE

Unannotated protein. (690 aa)

Predicted Functional Partners:

ptrB

0.548

ptrB-2

0.499

pepE

0.480

A4SQF4_AERS4

0.459

asmA

0.437

A4SIB8_AERS4

0.434

GCA_000820065_03146

0.434

macB-2

0.434

macA

0.434

Your Current Organism:

Aeromonas salmonicida

NCBI taxonomy Id: 29491
Other names: A. salmonicida subsp. salmonicida, Aeromonas salmonicida salmonicida, Aeromonas salmonicida subsp. salmonicida

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A4SIB8_AERS4	ppcE	GCA_000820065_02927	GCA_000820065_03145	Unannotated protein.	Unannotated protein.	0.434
A4SQF4_AERS4	ppcE	GCA_000820065_03512	GCA_000820065_03145	Unannotated protein.	Unannotated protein.	0.459
GCA_000820065_03146	macA	GCA_000820065_03146	GCA_000820065_03148	Unannotated protein.	Unannotated protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.773
GCA_000820065_03146	macB-2	GCA_000820065_03146	GCA_000820065_03147	Unannotated protein.	Unannotated protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.773
GCA_000820065_03146	ppcE	GCA_000820065_03146	GCA_000820065_03145	Unannotated protein.	Unannotated protein.	0.434
asmA	ppcE	GCA_000820065_03144	GCA_000820065_03145	Unannotated protein.	Unannotated protein.	0.437
macA	GCA_000820065_03146	GCA_000820065_03148	GCA_000820065_03146	Unannotated protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Unannotated protein.	0.773
macA	macB-2	GCA_000820065_03148	GCA_000820065_03147	Unannotated protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Unannotated protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.999
macA	ppcE	GCA_000820065_03148	GCA_000820065_03145	Unannotated protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	Unannotated protein.	0.434
macB-2	GCA_000820065_03146	GCA_000820065_03147	GCA_000820065_03146	Unannotated protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	Unannotated protein.	0.773
macB-2	macA	GCA_000820065_03147	GCA_000820065_03148	Unannotated protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	Unannotated protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.999
macB-2	ppcE	GCA_000820065_03147	GCA_000820065_03145	Unannotated protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	Unannotated protein.	0.434
pepE	ppcE	GCA_000820065_01161	GCA_000820065_03145	Unannotated protein; Belongs to the peptidase S51 family.	Unannotated protein.	0.480
ppcE	A4SIB8_AERS4	GCA_000820065_03145	GCA_000820065_02927	Unannotated protein.	Unannotated protein.	0.434
ppcE	A4SQF4_AERS4	GCA_000820065_03145	GCA_000820065_03512	Unannotated protein.	Unannotated protein.	0.459
ppcE	GCA_000820065_03146	GCA_000820065_03145	GCA_000820065_03146	Unannotated protein.	Unannotated protein.	0.434
ppcE	asmA	GCA_000820065_03145	GCA_000820065_03144	Unannotated protein.	Unannotated protein.	0.437
ppcE	macA	GCA_000820065_03145	GCA_000820065_03148	Unannotated protein.	Unannotated protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.	0.434
ppcE	macB-2	GCA_000820065_03145	GCA_000820065_03147	Unannotated protein.	Unannotated protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.	0.434
ppcE	pepE	GCA_000820065_03145	GCA_000820065_01161	Unannotated protein.	Unannotated protein; Belongs to the peptidase S51 family.	0.480

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.896

expected number of edges:

10

PPI enrichment p-value:

0.000465

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

10 of 23

2.15

6.76

1.43e-17

GO:0006520

Cellular amino acid metabolic process

11 of 151

1.37

2.55

3.12e-13

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 337

1.02

1.34

4.97e-10

GO:1901566

Organonitrogen compound biosynthetic process

11 of 394

0.96

1.17

2.29e-09

GO:0006139

Nucleobase-containing compound metabolic process

11 of 479

0.87

0.98

1.74e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

10 of 23

2.15

6.83

7.78e-18

GO:0016874

Ligase activity

11 of 89

1.6

3.75

1.12e-15

GO:0002161

aminoacyl-tRNA editing activity

3 of 7

2.14

2.08

8.04e-05

GO:0000049

tRNA binding

4 of 28

1.67

1.83

5.45e-05

GO:0005524

ATP binding

11 of 311

1.06

1.43

3.21e-10

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1203

0.47

0.39

0.00095

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:348

Aminoacyl-tRNA synthetase

5 of 15

2.03

2.81

1.17e-06

CL:350

Aminoacyl-tRNA synthetase

3 of 10

1.99

1.53

0.00094

CL:110

Translation, and Protein export

6 of 137

1.15

1.03

0.00059

CL:355

tRNA synthetases class I (M), and arginyl-tRNA aminoacylation

2 of 5

2.11

0.93

0.0182

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00970

Aminoacyl-tRNA biosynthesis

10 of 31

2.02

6.14

1.69e-17

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

11 of 1008

0.55

0.46

0.00029

GOCC:0005829

Cytosol

8 of 622

0.62

0.44

0.0089

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

10 of 22

2.17

7.11

1.71e-18

KW-0648

Protein biosynthesis

10 of 49

1.82

4.85

5.53e-16

KW-0436

Ligase

11 of 69

1.71

4.49

3.92e-17

KW-0067

ATP-binding

11 of 252

1.15

1.72

1.58e-11

KW-0820

tRNA-binding

3 of 19

1.71

1.39

0.0011

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13603

Leucyl-tRNA synthetase, Domain 2

3 of 3

2.51

1.94

0.00025

PF08264

Anticodon-binding domain of tRNA ligase

3 of 3

2.51

1.94

0.00025

PF09334

tRNA synthetases class I (M)

3 of 4

2.39

1.92

0.00025

PF00587

tRNA synthetase class II core domain (G, H, P, S and T)

2 of 3

2.33

1.04

0.0122

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00863

Threonyl and Alanyl tRNA synthetase second additional domain

2 of 2

2.51

1.18

0.0070

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