A4SQR6_AERS4 protein (Aeromonas salmonicida)

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

A4SQR6_AERS4

Unannotated protein. (110 aa)

Predicted Functional Partners:

A4SQR7_AERS4

0.554

A4SIR1_AERS4

0.532

A4SPD0_AERS4

0.469

gloA-2

0.469

queF

0.467

A4SHG8_AERS4

0.454

A4SQR8_AERS4

0.438

hisC

0.431

pabC

0.425

ilvE

0.425

Your Current Organism:

Aeromonas salmonicida

NCBI taxonomy Id: 29491
Other names: A. salmonicida subsp. salmonicida, Aeromonas salmonicida salmonicida, Aeromonas salmonicida subsp. salmonicida

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A4SHG8_AERS4	A4SQR6_AERS4	GCA_000820065_04099	GCA_000820065_03629	Unannotated protein.	Unannotated protein.	0.454
A4SIR1_AERS4	A4SQR6_AERS4	GCA_000820065_01876	GCA_000820065_03629	Unannotated protein.	Unannotated protein.	0.532
A4SPD0_AERS4	A4SQR6_AERS4	GCA_000820065_00079	GCA_000820065_03629	Unannotated protein.	Unannotated protein.	0.469
A4SQR6_AERS4	A4SHG8_AERS4	GCA_000820065_03629	GCA_000820065_04099	Unannotated protein.	Unannotated protein.	0.454
A4SQR6_AERS4	A4SIR1_AERS4	GCA_000820065_03629	GCA_000820065_01876	Unannotated protein.	Unannotated protein.	0.532
A4SQR6_AERS4	A4SPD0_AERS4	GCA_000820065_03629	GCA_000820065_00079	Unannotated protein.	Unannotated protein.	0.469
A4SQR6_AERS4	A4SQR7_AERS4	GCA_000820065_03629	GCA_000820065_03630	Unannotated protein.	Unannotated protein.	0.554
A4SQR6_AERS4	A4SQR8_AERS4	GCA_000820065_03629	GCA_000820065_03631	Unannotated protein.	Unannotated protein.	0.438
A4SQR6_AERS4	gloA-2	GCA_000820065_03629	GCA_000820065_01699	Unannotated protein.	Unannotated protein.	0.469
A4SQR6_AERS4	hisC	GCA_000820065_03629	GCA_000820065_00713	Unannotated protein.	Unannotated protein; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.431
A4SQR6_AERS4	ilvE	GCA_000820065_03629	GCA_000820065_04119	Unannotated protein.	Unannotated protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.425
A4SQR6_AERS4	pabC	GCA_000820065_03629	GCA_000820065_00662	Unannotated protein.	Unannotated protein.	0.425
A4SQR6_AERS4	queF	GCA_000820065_03629	GCA_000820065_03558	Unannotated protein.	Unannotated protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).	0.467
A4SQR7_AERS4	A4SQR6_AERS4	GCA_000820065_03630	GCA_000820065_03629	Unannotated protein.	Unannotated protein.	0.554
A4SQR7_AERS4	A4SQR8_AERS4	GCA_000820065_03630	GCA_000820065_03631	Unannotated protein.	Unannotated protein.	0.596
A4SQR8_AERS4	A4SQR6_AERS4	GCA_000820065_03631	GCA_000820065_03629	Unannotated protein.	Unannotated protein.	0.438
A4SQR8_AERS4	A4SQR7_AERS4	GCA_000820065_03631	GCA_000820065_03630	Unannotated protein.	Unannotated protein.	0.596
gloA-2	A4SQR6_AERS4	GCA_000820065_01699	GCA_000820065_03629	Unannotated protein.	Unannotated protein.	0.469
hisC	A4SQR6_AERS4	GCA_000820065_00713	GCA_000820065_03629	Unannotated protein; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	Unannotated protein.	0.431
hisC	ilvE	GCA_000820065_00713	GCA_000820065_04119	Unannotated protein; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	Unannotated protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.669

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

43

PPI enrichment p-value:

0.325

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

6 of 53

1.58

1.99

7.04e-06

GO:0050896

Response to stimulus

9 of 315

0.98

1.04

7.04e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

6 of 61

1.52

1.88

8.42e-06

GO:0016772

Transferase activity, transferring phosphorus-containing groups

7 of 234

1.0

0.94

0.00017

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2982

PAS domain superfamily, and GAF domain

9 of 31

1.99

5.18

3.35e-14

CL:2985

PAS domain

7 of 20

2.07

4.67

1.24e-11

CL:2986

PAS fold-4, and Signal transduction histidine kinase, phosphotransfer (Hpt) domain

6 of 15

2.13

4.29

3.52e-10

CL:2991

PAS fold-4, and Histidine Phosphotransfer domain

3 of 10

2.0

1.83

0.00021

CL:2994

Mixed, incl. Phytochrome chromophore attachment domain, and CheB methylesterase

2 of 5

2.13

1.18

0.0060

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

9 of 346

0.94

1.0

3.51e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

6 of 70

1.46

1.83

5.91e-06

KW-0418

Kinase

6 of 120

1.23

1.29

6.27e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

8 of 53

1.71

3.2

7.79e-10

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

8 of 56

1.68

3.14

7.79e-10

IPR005467

Histidine kinase domain

8 of 58

1.67

3.09

7.79e-10

IPR035965

PAS domain superfamily

8 of 59

1.66

3.07

7.79e-10

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

8 of 67

1.6

2.91

8.84e-10

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

8 of 57

1.67

3.29

1.11e-10

SM00091

PAS domain

7 of 57

1.62

2.77

6.22e-09

SM00387

Histidine kinase-like ATPases

7 of 60

1.59

2.72

6.22e-09

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

6 of 43

1.67

2.69

5.21e-08

SM00448

cheY-homologous receiver domain

6 of 58

1.54

2.28

2.20e-07

(more ...)

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