KRG22551.1 protein (Berkiella aquae) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

KRG22551.1

L,D-transpeptidase catalytic domain. (194 aa)

Predicted Functional Partners:

erfK

0.745

KRG21486.1

0.562

dacC

0.536

KRG22550.1

0.533

dacB

0.518

spoVD

0.517

KRG22552.1

0.458

KRG22848.1

0.400

Your Current Organism:

Berkiella aquae

NCBI taxonomy Id: 295108
Other names: C. Berkiella aquae, Candidatus Berkiella aquae, Coxiellaceae bacterium HT99, Legionella-like amoebal pathogen HT99

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRG21486.1	KRG22551.1	HT99x_01238	HT99x_00089	Flagellar basal body-associated protein FliL; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family.	L,D-transpeptidase catalytic domain.	0.562
KRG22550.1	KRG22551.1	HT99x_00088	HT99x_00089	Hypothetical protein.	L,D-transpeptidase catalytic domain.	0.533
KRG22551.1	KRG21486.1	HT99x_00089	HT99x_01238	L,D-transpeptidase catalytic domain.	Flagellar basal body-associated protein FliL; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family.	0.562
KRG22551.1	KRG22550.1	HT99x_00089	HT99x_00088	L,D-transpeptidase catalytic domain.	Hypothetical protein.	0.533
KRG22551.1	KRG22552.1	HT99x_00089	HT99x_00090	L,D-transpeptidase catalytic domain.	DNA polymerase III subunit epsilon.	0.458
KRG22551.1	KRG22848.1	HT99x_00089	HT99x_00389	L,D-transpeptidase catalytic domain.	ComEC family competence protein.	0.400
KRG22551.1	dacB	HT99x_00089	HT99x_00051	L,D-transpeptidase catalytic domain.	D-alanyl-D-alanine carboxypeptidase DacB precursor.	0.518
KRG22551.1	dacC	HT99x_00089	HT99x_00924	L,D-transpeptidase catalytic domain.	D-alanyl-D-alanine carboxypeptidase DacC precursor; Belongs to the peptidase S11 family.	0.536
KRG22551.1	erfK	HT99x_00089	HT99x_00539	L,D-transpeptidase catalytic domain.	Putative L,D-transpeptidase ErfK/SrfK precursor.	0.745
KRG22551.1	spoVD	HT99x_00089	HT99x_00920	L,D-transpeptidase catalytic domain.	Stage V sporulation protein D.	0.517
KRG22552.1	KRG22551.1	HT99x_00090	HT99x_00089	DNA polymerase III subunit epsilon.	L,D-transpeptidase catalytic domain.	0.458
KRG22848.1	KRG22551.1	HT99x_00389	HT99x_00089	ComEC family competence protein.	L,D-transpeptidase catalytic domain.	0.400
dacB	KRG22551.1	HT99x_00051	HT99x_00089	D-alanyl-D-alanine carboxypeptidase DacB precursor.	L,D-transpeptidase catalytic domain.	0.518
dacB	dacC	HT99x_00051	HT99x_00924	D-alanyl-D-alanine carboxypeptidase DacB precursor.	D-alanyl-D-alanine carboxypeptidase DacC precursor; Belongs to the peptidase S11 family.	0.685
dacB	spoVD	HT99x_00051	HT99x_00920	D-alanyl-D-alanine carboxypeptidase DacB precursor.	Stage V sporulation protein D.	0.709
dacC	KRG22551.1	HT99x_00924	HT99x_00089	D-alanyl-D-alanine carboxypeptidase DacC precursor; Belongs to the peptidase S11 family.	L,D-transpeptidase catalytic domain.	0.536
dacC	dacB	HT99x_00924	HT99x_00051	D-alanyl-D-alanine carboxypeptidase DacC precursor; Belongs to the peptidase S11 family.	D-alanyl-D-alanine carboxypeptidase DacB precursor.	0.685
dacC	erfK	HT99x_00924	HT99x_00539	D-alanyl-D-alanine carboxypeptidase DacC precursor; Belongs to the peptidase S11 family.	Putative L,D-transpeptidase ErfK/SrfK precursor.	0.631
dacC	spoVD	HT99x_00924	HT99x_00920	D-alanyl-D-alanine carboxypeptidase DacC precursor; Belongs to the peptidase S11 family.	Stage V sporulation protein D.	0.974
erfK	KRG22551.1	HT99x_00539	HT99x_00089	Putative L,D-transpeptidase ErfK/SrfK precursor.	L,D-transpeptidase catalytic domain.	0.745

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006096

Glycolytic process

7 of 11

2.34

5.49

2.87e-12

GO:0005975

Carbohydrate metabolic process

11 of 145

1.41

2.68

5.14e-13

GO:0006091

Generation of precursor metabolites and energy

8 of 88

1.49

2.55

1.34e-09

GO:0019637

Organophosphate metabolic process

8 of 165

1.22

1.63

1.21e-07

GO:0006002

Fructose 6-phosphate metabolic process

2 of 2

2.53

1.55

0.0014

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003872

6-phosphofructokinase activity

2 of 2

2.53

0.84

0.0298

GO:0016832

Aldehyde-lyase activity

2 of 6

2.06

0.78

0.0346

GO:0016861

Intramolecular oxidoreductase activity, interconverting aldoses and ketoses

2 of 8

1.93

0.72

0.0443

GO:0046872

Metal ion binding

6 of 417

0.69

0.4

0.0443

GO:0003824

Catalytic activity

11 of 1849

0.31

0.24

0.0443

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

9 of 1020

0.48

0.32

0.0314

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:892

Pentose phosphate pathway, and Glycolysis / Gluconeogenesis

11 of 30

2.1

7.15

5.13e-20

CL:893

Glycolytic process, and Phosphoenolpyruvate carboxykinase activity

9 of 18

2.23

6.75

1.77e-16

CL:895

Glycolytic process, and Glyceraldehyde/Erythrose phosphate dehydrogenase family

5 of 11

2.19

3.55

4.52e-08

CL:896

Phosphofructokinase, and Aldehyde-lyase activity

3 of 6

2.23

1.94

0.00019

CL:907

Glyceraldehyde/Erythrose phosphate dehydrogenase family, and Glycolysis

2 of 5

2.13

0.94

0.0172

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

mtt00030

Pentose phosphate pathway

7 of 18

2.12

4.96

4.06e-12

mtt00051

Fructose and mannose metabolism

6 of 11

2.27

4.96

2.90e-11

mtt00010

Glycolysis / Gluconeogenesis

7 of 31

1.89

4.05

3.01e-11

mtt01200

Carbon metabolism

10 of 86

1.6

3.5

8.61e-14

mtt01230

Biosynthesis of amino acids

9 of 111

1.44

2.61

2.90e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005945

6-phosphofructokinase complex

2 of 2

2.53

1.05

0.0123

GOCC:0005737

Cytoplasm

9 of 819

0.57

0.4

0.0123

GOCC:0005622

Intracellular

10 of 1182

0.46

0.34

0.0123

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

6 of 9

2.36

4.85

1.17e-10

KW-0460

Magnesium

5 of 80

1.33

1.31

0.00022

KW-0021

Allosteric enzyme

2 of 4

2.23

1.13

0.0077

KW-0413

Isomerase

3 of 63

1.21

0.67

0.0256

KW-0963

Cytoplasm

5 of 212

0.91

0.62

0.0097

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00365

Phosphofructokinase

2 of 2

2.53

0.88

0.0248

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