KRG21574.1 protein (Berkiella aquae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

KRG21574.1

Hypothetical protein. (416 aa)

Predicted Functional Partners:

KRG21305.1

0.807

KRG22649.1

0.777

KRG21610.1

0.777

ftsK

0.758

ctpB

0.698

KRG20471.1

0.601

pbpE_3

0.590

KRG21694.1

0.559

KRG20878.1

0.544

acpP

0.531

Your Current Organism:

Berkiella aquae

NCBI taxonomy Id: 295108
Other names: C. Berkiella aquae, Candidatus Berkiella aquae, Coxiellaceae bacterium HT99, Legionella-like amoebal pathogen HT99

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRG20471.1	KRG21574.1	HT99x_02400	HT99x_01327	Hypothetical protein.	Hypothetical protein.	0.601
KRG20471.1	KRG21610.1	HT99x_02400	HT99x_01363	Hypothetical protein.	Hypothetical protein.	0.631
KRG20471.1	KRG22649.1	HT99x_02400	HT99x_00187	Hypothetical protein.	Hypothetical protein.	0.632
KRG20878.1	KRG21305.1	HT99x_02095	HT99x_01481	Long-chain-fatty-acid--AMP ligase FadD29.	Hypothetical protein.	0.604
KRG20878.1	KRG21574.1	HT99x_02095	HT99x_01327	Long-chain-fatty-acid--AMP ligase FadD29.	Hypothetical protein.	0.544
KRG20878.1	acpP	HT99x_02095	HT99x_00407	Long-chain-fatty-acid--AMP ligase FadD29.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.967
KRG21305.1	KRG20878.1	HT99x_01481	HT99x_02095	Hypothetical protein.	Long-chain-fatty-acid--AMP ligase FadD29.	0.604
KRG21305.1	KRG21574.1	HT99x_01481	HT99x_01327	Hypothetical protein.	Hypothetical protein.	0.807
KRG21574.1	KRG20471.1	HT99x_01327	HT99x_02400	Hypothetical protein.	Hypothetical protein.	0.601
KRG21574.1	KRG20878.1	HT99x_01327	HT99x_02095	Hypothetical protein.	Long-chain-fatty-acid--AMP ligase FadD29.	0.544
KRG21574.1	KRG21305.1	HT99x_01327	HT99x_01481	Hypothetical protein.	Hypothetical protein.	0.807
KRG21574.1	KRG21610.1	HT99x_01327	HT99x_01363	Hypothetical protein.	Hypothetical protein.	0.777
KRG21574.1	KRG21694.1	HT99x_01327	HT99x_01447	Hypothetical protein.	Hypothetical protein.	0.559
KRG21574.1	KRG22649.1	HT99x_01327	HT99x_00187	Hypothetical protein.	Hypothetical protein.	0.777
KRG21574.1	acpP	HT99x_01327	HT99x_00407	Hypothetical protein.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.531
KRG21574.1	ctpB	HT99x_01327	HT99x_00532	Hypothetical protein.	Carboxy-terminal processing protease CtpB precursor; Belongs to the peptidase S41A family.	0.698
KRG21574.1	ftsK	HT99x_01327	HT99x_02872	Hypothetical protein.	DNA translocase FtsK.	0.758
KRG21574.1	pbpE_3	HT99x_01327	HT99x_02428	Hypothetical protein.	Penicillin-binding protein 4*.	0.590
KRG21610.1	KRG20471.1	HT99x_01363	HT99x_02400	Hypothetical protein.	Hypothetical protein.	0.631
KRG21610.1	KRG21574.1	HT99x_01363	HT99x_01327	Hypothetical protein.	Hypothetical protein.	0.777

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

11

PPI enrichment p-value:

3.84e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006525

Arginine metabolic process

11 of 34

2.23

8.23

2.82e-21

GO:0006526

Arginine biosynthetic process

9 of 17

2.45

8.04

4.90e-18

GO:0006591

Ornithine metabolic process

4 of 6

2.55

3.56

1.65e-07

GO:0042450

Arginine biosynthetic process via ornithine

2 of 2

2.72

1.57

0.0014

GO:0044205

De novo UMP biosynthetic process

2 of 7

2.18

1.12

0.0079

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0103045

Methione N-acyltransferase activity

2 of 2

2.72

0.93

0.0203

GO:0004088

Carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

2 of 2

2.72

0.93

0.0203

GO:0004042

acetyl-CoA:L-glutamate N-acetyltransferase activity

2 of 2

2.72

0.93

0.0203

GO:0016774

Phosphotransferase activity, carboxyl group as acceptor

2 of 7

2.18

0.82

0.0303

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

3 of 51

1.49

0.73

0.0303

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1829

0.5

0.42

0.00052

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1505

Arginine biosynthesis, and Amino acid antiporter

9 of 15

2.5

8.22

4.37e-18

CL:1510

Arginine biosynthesis

6 of 6

2.72

6.12

1.70e-12

CL:1367

Cellular amino acid biosynthetic process, and Ribonucleoside monophosphate biosynthetic process

11 of 152

1.58

3.6

3.78e-15

CL:1525

Amino acid antiporter, and Arginine catabolic process to ornithine

2 of 5

2.33

1.03

0.0127

CL:1578

Pyrimidine biosynthesis, and Dihydroorotase, conserved site

2 of 6

2.25

0.99

0.0148

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pfn00220

Arginine biosynthesis

9 of 36

2.12

6.25

3.12e-16

pfn00250

Alanine, aspartate and glutamate metabolism

4 of 39

1.74

1.95

3.78e-05

pfn01230

Biosynthesis of amino acids

7 of 179

1.32

1.75

6.17e-07

pfn01210

2-Oxocarboxylic acid metabolism

4 of 51

1.62

1.75

6.84e-05

pfn01110

Biosynthesis of secondary metabolites

8 of 614

0.84

0.78

6.84e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005951

Carbamoyl-phosphate synthase complex

2 of 2

2.72

1.18

0.0073

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0055

Arginine biosynthesis

9 of 13

2.56

8.87

2.96e-19

KW-0963

Cytoplasm

8 of 311

1.13

1.38

8.14e-07

KW-0665

Pyrimidine biosynthesis

2 of 10

2.03

1.0

0.0124

KW-0436

Ligase

3 of 73

1.34

0.8

0.0152

KW-0808

Transferase

5 of 407

0.81

0.51

0.0216

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00696

Amino acid kinase family

3 of 6

2.42

1.85

0.00035

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036393

Acetylglutamate kinase-like superfamily

3 of 6

2.42

1.71

0.00065

IPR001048

Aspartate/glutamate/uridylate kinase

3 of 6

2.42

1.71

0.00065

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (30%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About