KRG21312.1 protein (Berkiella aquae) - STRING interaction network

Nodes:

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second shell of interactors

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Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

KRG21312.1

Hypothetical protein. (560 aa)

Predicted Functional Partners:

frzE

0.996

KRG18465.1

0.977

KRG22659.1

0.976

divK_2

0.950

cph2_4

0.950

tcrA

0.937

barA_1

0.929

cheA

0.912

cheW

0.908

KRG22202.1

0.908

Your Current Organism:

Berkiella aquae

NCBI taxonomy Id: 295108
Other names: C. Berkiella aquae, Candidatus Berkiella aquae, Coxiellaceae bacterium HT99, Legionella-like amoebal pathogen HT99

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRG18465.1	KRG21312.1	HT99x_02996	HT99x_01488	Putative diguanylate cyclase.	Hypothetical protein.	0.977
KRG18465.1	KRG22202.1	HT99x_02996	HT99x_00621	Putative diguanylate cyclase.	CheW-like domain protein.	0.961
KRG18465.1	KRG22659.1	HT99x_02996	HT99x_00197	Putative diguanylate cyclase.	Sensory histidine kinase AtoS.	0.997
KRG18465.1	barA_1	HT99x_02996	HT99x_01179	Putative diguanylate cyclase.	Signal transduction histidine-protein kinase BarA.	0.998
KRG18465.1	cheA	HT99x_02996	HT99x_00162	Putative diguanylate cyclase.	Chemotaxis protein CheA.	0.969
KRG18465.1	cheW	HT99x_02996	HT99x_00163	Putative diguanylate cyclase.	Chemotaxis protein CheW.	0.971
KRG18465.1	cph2_4	HT99x_02996	HT99x_02754	Putative diguanylate cyclase.	Phytochrome-like protein cph2.	0.999
KRG18465.1	divK_2	HT99x_02996	HT99x_01350	Putative diguanylate cyclase.	Polar-differentiation response regulator DivK.	0.999
KRG18465.1	frzE	HT99x_02996	HT99x_00623	Putative diguanylate cyclase.	Gliding motility regulatory protein.	0.997
KRG18465.1	tcrA	HT99x_02996	HT99x_00429	Putative diguanylate cyclase.	Transcriptional regulatory protein TcrA.	0.997
KRG21312.1	KRG18465.1	HT99x_01488	HT99x_02996	Hypothetical protein.	Putative diguanylate cyclase.	0.977
KRG21312.1	KRG22202.1	HT99x_01488	HT99x_00621	Hypothetical protein.	CheW-like domain protein.	0.908
KRG21312.1	KRG22659.1	HT99x_01488	HT99x_00197	Hypothetical protein.	Sensory histidine kinase AtoS.	0.976
KRG21312.1	barA_1	HT99x_01488	HT99x_01179	Hypothetical protein.	Signal transduction histidine-protein kinase BarA.	0.929
KRG21312.1	cheA	HT99x_01488	HT99x_00162	Hypothetical protein.	Chemotaxis protein CheA.	0.912
KRG21312.1	cheW	HT99x_01488	HT99x_00163	Hypothetical protein.	Chemotaxis protein CheW.	0.908
KRG21312.1	cph2_4	HT99x_01488	HT99x_02754	Hypothetical protein.	Phytochrome-like protein cph2.	0.950
KRG21312.1	divK_2	HT99x_01488	HT99x_01350	Hypothetical protein.	Polar-differentiation response regulator DivK.	0.950
KRG21312.1	frzE	HT99x_01488	HT99x_00623	Hypothetical protein.	Gliding motility regulatory protein.	0.996
KRG21312.1	tcrA	HT99x_01488	HT99x_00429	Hypothetical protein.	Transcriptional regulatory protein TcrA.	0.937

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.802

expected number of edges:

11

PPI enrichment p-value:

2.54e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045638

Negative regulation of myeloid cell differentiation

4 of 65

2.05

1.87

0.00019

GO:0045637

Regulation of myeloid cell differentiation

5 of 151

1.78

1.81

0.00012

GO:0045596

Negative regulation of cell differentiation

6 of 451

1.39

0.00019

GO:0007389

Pattern specification process

5 of 328

1.45

1.36

0.00039

GO:0009880

Embryonic pattern specification

3 of 55

2.0

1.34

0.0025

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000978

RNA polymerase II cis-regulatory region sequence-specific DNA binding

9 of 969

1.23

1.66

1.06e-07

GO:0003700

DNA-binding transcription factor activity

10 of 1187

1.19

1.64

1.60e-08

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

5 of 326

1.45

1.52

0.00010

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

9 of 1118

1.17

1.51

1.51e-07

GO:0003677

DNA binding

10 of 2214

0.92

1.0

6.34e-07

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:22829811

(2012) Epigenetic alterations in bladder cancer and their potential clinical implications.

4 of 17

2.64

2.58

1.63e-05

PMID:22495965

(2012) A novel 13 base pair insertion in the sonic hedgehog ZRS limb enhancer (ZRSLMBR1) causes preaxial polydactyly with triphalangeal thumb.

3 of 9

2.79

1.71

0.00076

PMID:26572684

(2015) Transcriptome profiling reveals distinctive traits of retinol metabolism and neonatal parallels in the MRLMpJ mouse.

3 of 11

2.7

1.68

0.00084

PMID:36418415

(2022) The autism-associated Meis2 gene is necessary for cardiac baroreflex regulation in mice.

3 of 13

2.63

1.64

0.00097

PMID:28874668

(2017) Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation.

3 of 19

2.46

1.45

0.0021

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26589

Embryonic skeletal system morphogenesis, and N-terminal of Homeobox Meis and PKNOX1

6 of 25

2.64

5.58

1.61e-11

CL:26624

Mixed, incl. Protein of unknown function (DUF3528), and N-terminal of Homeobox Meis and PKNOX1

4 of 5

3.17

4.61

3.85e-09

CL:26433

Homeobox, and Neuron fate commitment

7 of 125

2.01

4.2

1.26e-10

CL:32174

Mixed, incl. Adiponectin binding, and G2 nidogen domain and fibulin

2 of 7

2.72

1.24

0.0055

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa05202

Transcriptional misregulation in cancer

4 of 141

1.72

1.63

0.00027

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005634

Nucleus

9 of 3900

0.63

0.4

0.0259

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0371

Homeobox

7 of 203

1.8

3.38

1.55e-09

KW-0238

DNA-binding

8 of 642

1.36

2.01

3.42e-08

KW-0539

Nucleus

8 of 1146

1.11

1.29

2.14e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16493

N-terminal of Homeobox Meis and PKNOX1

2 of 5

2.87

1.04

0.0130

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00389

Homeodomain

7 of 208

1.79

3.25

3.60e-09

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