KRG21434.1 protein (Berkiella aquae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

KRG21434.1

Fatty acid desaturase. (287 aa)

Predicted Functional Partners:

KRG20878.1

0.581

nlhH_2

0.557

nrdB

0.494

ascD

0.456

KRG21435.1

0.452

KRG22421.1

0.451

fpr

0.424

KRG22003.1

0.407

Your Current Organism:

Berkiella aquae

NCBI taxonomy Id: 295108
Other names: C. Berkiella aquae, Candidatus Berkiella aquae, Coxiellaceae bacterium HT99, Legionella-like amoebal pathogen HT99

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRG20878.1	KRG21434.1	HT99x_02095	HT99x_01610	Long-chain-fatty-acid--AMP ligase FadD29.	Fatty acid desaturase.	0.581
KRG20878.1	KRG22003.1	HT99x_02095	HT99x_01197	Long-chain-fatty-acid--AMP ligase FadD29.	Acyltransferase.	0.811
KRG20878.1	KRG22421.1	HT99x_02095	HT99x_00843	Long-chain-fatty-acid--AMP ligase FadD29.	CobQ/CobB/MinD/ParA nucleotide binding domain protein.	0.611
KRG20878.1	ascD	HT99x_02095	HT99x_00521	Long-chain-fatty-acid--AMP ligase FadD29.	CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3- dehydrase reductase.	0.907
KRG20878.1	fpr	HT99x_02095	HT99x_00519	Long-chain-fatty-acid--AMP ligase FadD29.	Ferredoxin--NADP reductase.	0.629
KRG20878.1	nlhH_2	HT99x_02095	HT99x_01609	Long-chain-fatty-acid--AMP ligase FadD29.	Carboxylesterase NlhH.	0.973
KRG20878.1	nrdB	HT99x_02095	HT99x_01539	Long-chain-fatty-acid--AMP ligase FadD29.	Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.	0.844
KRG21434.1	KRG20878.1	HT99x_01610	HT99x_02095	Fatty acid desaturase.	Long-chain-fatty-acid--AMP ligase FadD29.	0.581
KRG21434.1	KRG21435.1	HT99x_01610	HT99x_01611	Fatty acid desaturase.	Hypothetical protein.	0.452
KRG21434.1	KRG22003.1	HT99x_01610	HT99x_01197	Fatty acid desaturase.	Acyltransferase.	0.407
KRG21434.1	KRG22421.1	HT99x_01610	HT99x_00843	Fatty acid desaturase.	CobQ/CobB/MinD/ParA nucleotide binding domain protein.	0.451
KRG21434.1	ascD	HT99x_01610	HT99x_00521	Fatty acid desaturase.	CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3- dehydrase reductase.	0.456
KRG21434.1	fpr	HT99x_01610	HT99x_00519	Fatty acid desaturase.	Ferredoxin--NADP reductase.	0.424
KRG21434.1	nlhH_2	HT99x_01610	HT99x_01609	Fatty acid desaturase.	Carboxylesterase NlhH.	0.557
KRG21434.1	nrdB	HT99x_01610	HT99x_01539	Fatty acid desaturase.	Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.	0.494
KRG21435.1	KRG21434.1	HT99x_01611	HT99x_01610	Hypothetical protein.	Fatty acid desaturase.	0.452
KRG22003.1	KRG20878.1	HT99x_01197	HT99x_02095	Acyltransferase.	Long-chain-fatty-acid--AMP ligase FadD29.	0.811
KRG22003.1	KRG21434.1	HT99x_01197	HT99x_01610	Acyltransferase.	Fatty acid desaturase.	0.407
KRG22421.1	KRG20878.1	HT99x_00843	HT99x_02095	CobQ/CobB/MinD/ParA nucleotide binding domain protein.	Long-chain-fatty-acid--AMP ligase FadD29.	0.611
KRG22421.1	KRG21434.1	HT99x_00843	HT99x_01610	CobQ/CobB/MinD/ParA nucleotide binding domain protein.	Fatty acid desaturase.	0.451

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

23

PPI enrichment p-value:

1.66e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016180

snRNA processing

7 of 16

2.99

8.32

2.01e-16

GO:0034472

snRNA 3-end processing

4 of 13

2.84

4.25

1.25e-08

GO:0016070

RNA metabolic process

10 of 870

1.41

2.5

3.12e-11

GO:0010467

Gene expression

10 of 1083

1.31

2.13

2.05e-10

GO:0006351

Transcription, DNA-templated

3 of 96

1.84

1.43

0.0012

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

2 of 18

2.39

0.73

0.0472

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032039

Integrator complex

5 of 5

3.35

6.57

1.03e-12

GO:0140513

Nuclear protein-containing complex

7 of 475

1.52

2.29

1.09e-07

GO:0000428

DNA-directed RNA polymerase complex

3 of 66

2.01

1.69

0.00045

GO:0005665

RNA polymerase II, core complex

2 of 10

2.65

1.62

0.0011

GO:0032991

Protein-containing complex

8 of 1801

1.0

1.02

2.52e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7331

Integrator complex, and Response to ionizing radiation

7 of 11

3.15

8.94

2.31e-17

CL:7336

Integrator complex, and Zn-dependent metallo-hydrolase RNA specificity domain

6 of 6

3.35

8.24

8.24e-16

CL:5446

RNA polymerase II, core complex, and RNA polymerase Rpb2, domain 5

2 of 5

2.95

1.58

0.0014

CL:5426

Transcription, DNA-templated, and Chromosome

3 of 67

2.0

1.46

0.0014

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gtt03020

RNA polymerase

3 of 21

2.5

2.57

1.45e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6807505

RNA polymerase II transcribes snRNA genes

10 of 58

2.59

10.3

1.24e-22

MAP-73857

RNA Polymerase II Transcription

10 of 434

1.71

4.1

1.56e-14

MAP-74160

Gene expression (Transcription)

10 of 585

1.58

3.39

1.98e-13

MAP-9018519

Estrogen-dependent gene expression

3 of 23

2.46

2.36

3.71e-05

MAP-77075

RNA Pol II CTD phosphorylation and interaction with CE

3 of 27

2.39

2.29

4.63e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032039

Integrator complex

5 of 5

3.35

6.53

1.26e-12

GOCC:0005634

Nucleus

9 of 1088

1.27

1.83

1.40e-08

GOCC:0005665

RNA polymerase II, core complex

2 of 7

2.8

1.75

0.00066

GOCC:0032991

Protein-containing complex

9 of 2275

0.95

0.99

6.37e-06

GOCC:0043229

Intracellular organelle

10 of 4481

0.7

0.62

6.13e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

2 of 19

2.37

1.12

0.0085

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR022712

Beta-Casp domain

2 of 4

3.05

1.1

0.0104

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01027

Beta-Casp domain

2 of 4

3.05

1.66

0.0010

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About