KRG20929.1 protein (Berkiella aquae) - STRING interaction network

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Score

KRG20929.1

Phosphotransferase enzyme family protein. (341 aa)

Predicted Functional Partners:

hddC_2

0.998

djlA

0.915

tsaE

0.912

nagZ

0.797

manC1_1

0.756

gph_1

0.753

glmU

0.732

lptD

0.648

hddC_3

0.552

ampD

0.542

Your Current Organism:

Berkiella aquae

NCBI taxonomy Id: 295108
Other names: C. Berkiella aquae, Candidatus Berkiella aquae, Coxiellaceae bacterium HT99, Legionella-like amoebal pathogen HT99

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRG20929.1	ampD	HT99x_01849	HT99x_01490	Phosphotransferase enzyme family protein.	1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD.	0.542
KRG20929.1	djlA	HT99x_01849	HT99x_01847	Phosphotransferase enzyme family protein.	DnaJ-like protein DjlA; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.	0.915
KRG20929.1	glmU	HT99x_01849	HT99x_00469	Phosphotransferase enzyme family protein.	Bifunctional protein GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	0.732
KRG20929.1	gph_1	HT99x_01849	HT99x_00145	Phosphotransferase enzyme family protein.	Phosphoglycolate phosphatase.	0.753
KRG20929.1	hddC_2	HT99x_01849	HT99x_01848	Phosphotransferase enzyme family protein.	D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase.	0.998
KRG20929.1	hddC_3	HT99x_01849	HT99x_02549	Phosphotransferase enzyme family protein.	D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase.	0.552
KRG20929.1	lptD	HT99x_01849	HT99x_01850	Phosphotransferase enzyme family protein.	LPS-assembly protein LptD precursor; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.	0.648
KRG20929.1	manC1_1	HT99x_01849	HT99x_01146	Phosphotransferase enzyme family protein.	Mannose-1-phosphate guanylyltransferase 1; Belongs to the mannose-6-phosphate isomerase type 2 family.	0.756
KRG20929.1	nagZ	HT99x_01849	HT99x_00362	Phosphotransferase enzyme family protein.	Beta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.	0.797
KRG20929.1	tsaE	HT99x_01849	HT99x_02290	Phosphotransferase enzyme family protein.	tRNA threonylcarbamoyladenosine biosynthesis protein TsaE.	0.912
ampD	KRG20929.1	HT99x_01490	HT99x_01849	1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD.	Phosphotransferase enzyme family protein.	0.542
ampD	nagZ	HT99x_01490	HT99x_00362	1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD.	Beta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.	0.773
djlA	KRG20929.1	HT99x_01847	HT99x_01849	DnaJ-like protein DjlA; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.	Phosphotransferase enzyme family protein.	0.915
djlA	hddC_2	HT99x_01847	HT99x_01848	DnaJ-like protein DjlA; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.	D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase.	0.931
djlA	lptD	HT99x_01847	HT99x_01850	DnaJ-like protein DjlA; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.	LPS-assembly protein LptD precursor; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.	0.564
glmU	KRG20929.1	HT99x_00469	HT99x_01849	Bifunctional protein GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	Phosphotransferase enzyme family protein.	0.732
glmU	hddC_2	HT99x_00469	HT99x_01848	Bifunctional protein GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase.	0.576
glmU	hddC_3	HT99x_00469	HT99x_02549	Bifunctional protein GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase.	0.601
glmU	manC1_1	HT99x_00469	HT99x_01146	Bifunctional protein GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	Mannose-1-phosphate guanylyltransferase 1; Belongs to the mannose-6-phosphate isomerase type 2 family.	0.467
glmU	tsaE	HT99x_00469	HT99x_02290	Bifunctional protein GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	tRNA threonylcarbamoyladenosine biosynthesis protein TsaE.	0.607