Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hscBHypothetical protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (168 aa)    
Predicted Functional Partners:
fdx_2
2Fe-2S ferredoxin.
 
  
 0.998
nifU_2
NifU-like protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
 
 0.998
hscA
Chaperone protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
 
 0.995
iscS
Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
 
 0.994
KRG18186.1
Hypothetical protein.
 
  
 0.993
iscA
Iron-binding protein IscA; Belongs to the HesB/IscA family.
 
 
  0.988
iscR
HTH-type transcriptional regulator IscR.
  
  
 0.984
nifU_1
NifU-like protein.
  
 0.979
dnaK_1
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.977
KRG22093.1
Frataxin-like protein; Belongs to the frataxin family.
  
 
 0.894
Your Current Organism:
Berkiella aquae
NCBI taxonomy Id: 295108
Other names: C. Berkiella aquae, Candidatus Berkiella aquae, Coxiellaceae bacterium HT99, Legionella-like amoebal pathogen HT99
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