node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHL34738.1 | SHL42922.1 | SAMN05444387_0376 | SAMN05444387_0587 | Curved DNA-binding protein. | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | 0.750 |
SHL34738.1 | clpP | SAMN05444387_0376 | SAMN05444387_3511 | Curved DNA-binding protein. | ATP-dependent Clp protease, protease subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.570 |
SHL34738.1 | dnaK | SAMN05444387_0376 | SAMN05444387_0638 | Curved DNA-binding protein. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.995 |
SHL34738.1 | groL | SAMN05444387_0376 | SAMN05444387_3654 | Curved DNA-binding protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.722 |
SHL34738.1 | groS | SAMN05444387_0376 | SAMN05444387_3656 | Curved DNA-binding protein. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.611 |
SHL34738.1 | grpE | SAMN05444387_0376 | SAMN05444387_2796 | Curved DNA-binding protein. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.842 |
SHL34738.1 | htpG | SAMN05444387_0376 | SAMN05444387_3114 | Curved DNA-binding protein. | Molecular chaperone HtpG. | 0.962 |
SHL34738.1 | lon | SAMN05444387_0376 | SAMN05444387_4479 | Curved DNA-binding protein. | ATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.560 |
SHL42922.1 | SHL34738.1 | SAMN05444387_0587 | SAMN05444387_0376 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Curved DNA-binding protein. | 0.750 |
SHL42922.1 | SHN14954.1 | SAMN05444387_0587 | SAMN05444387_4354 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | DnaJ domain-containing protein. | 0.709 |
SHL42922.1 | clpP | SAMN05444387_0587 | SAMN05444387_3511 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, protease subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.949 |
SHL42922.1 | dnaJ | SAMN05444387_0587 | SAMN05444387_2795 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.759 |
SHL42922.1 | dnaK | SAMN05444387_0587 | SAMN05444387_0638 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.956 |
SHL42922.1 | groL | SAMN05444387_0587 | SAMN05444387_3654 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.678 |
SHL42922.1 | groS | SAMN05444387_0587 | SAMN05444387_3656 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.618 |
SHL42922.1 | grpE | SAMN05444387_0587 | SAMN05444387_2796 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.773 |
SHL42922.1 | htpG | SAMN05444387_0587 | SAMN05444387_3114 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Molecular chaperone HtpG. | 0.706 |
SHL42922.1 | lon | SAMN05444387_0587 | SAMN05444387_4479 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | ATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.636 |
SHN14954.1 | SHL42922.1 | SAMN05444387_4354 | SAMN05444387_0587 | DnaJ domain-containing protein. | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | 0.709 |
SHN14954.1 | clpP | SAMN05444387_4354 | SAMN05444387_3511 | DnaJ domain-containing protein. | ATP-dependent Clp protease, protease subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.570 |