node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHL59248.1 | SHM83016.1 | SAMN05444387_1017 | SAMN05444387_3327 | Ribonucleoside-diphosphate reductase alpha chain. | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.988 |
SHL59248.1 | dnaN | SAMN05444387_1017 | SAMN05444387_4708 | Ribonucleoside-diphosphate reductase alpha chain. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.717 |
SHL59248.1 | dut | SAMN05444387_1017 | SAMN05444387_1599 | Ribonucleoside-diphosphate reductase alpha chain. | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.810 |
SHL59248.1 | gmk | SAMN05444387_1017 | SAMN05444387_3917 | Ribonucleoside-diphosphate reductase alpha chain. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.780 |
SHL59248.1 | ndk | SAMN05444387_1017 | SAMN05444387_2711 | Ribonucleoside-diphosphate reductase alpha chain. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.787 |
SHL59248.1 | thyA | SAMN05444387_1017 | SAMN05444387_2019 | Ribonucleoside-diphosphate reductase alpha chain. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.727 |
SHL95698.1 | SHM83016.1 | SAMN05444387_1541 | SAMN05444387_3327 | Regulator of protease activity HflC, stomatin/prohibitin superfamily. | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.565 |
SHM83016.1 | SHL59248.1 | SAMN05444387_3327 | SAMN05444387_1017 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Ribonucleoside-diphosphate reductase alpha chain. | 0.988 |
SHM83016.1 | SHL95698.1 | SAMN05444387_3327 | SAMN05444387_1541 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Regulator of protease activity HflC, stomatin/prohibitin superfamily. | 0.565 |
SHM83016.1 | SHM83038.1 | SAMN05444387_3327 | SAMN05444387_3328 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | DNA-binding protein HU-beta; Belongs to the bacterial histone-like protein family. | 0.623 |
SHM83016.1 | SHN10858.1 | SAMN05444387_3327 | SAMN05444387_4148 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.988 |
SHM83016.1 | dnaN | SAMN05444387_3327 | SAMN05444387_4708 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.693 |
SHM83016.1 | dut | SAMN05444387_3327 | SAMN05444387_1599 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.621 |
SHM83016.1 | gmk | SAMN05444387_3327 | SAMN05444387_3917 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.572 |
SHM83016.1 | ndk | SAMN05444387_3327 | SAMN05444387_2711 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.604 |
SHM83016.1 | ruvX | SAMN05444387_3327 | SAMN05444387_0528 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Putative holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | 0.745 |
SHM83016.1 | thyA | SAMN05444387_3327 | SAMN05444387_2019 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.566 |
SHM83038.1 | SHM83016.1 | SAMN05444387_3328 | SAMN05444387_3327 | DNA-binding protein HU-beta; Belongs to the bacterial histone-like protein family. | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.623 |
SHN10858.1 | SHM83016.1 | SAMN05444387_4148 | SAMN05444387_3327 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.988 |
SHN10858.1 | dnaN | SAMN05444387_4148 | SAMN05444387_4708 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.717 |