node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHL52756.1 | dnaN | SAMN05444387_0817 | SAMN05444387_4708 | DNA topoisomerase-1. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.487 |
SHL52756.1 | polA | SAMN05444387_0817 | SAMN05444387_2170 | DNA topoisomerase-1. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.522 |
SHL52756.1 | rnhB | SAMN05444387_0817 | SAMN05444387_3785 | DNA topoisomerase-1. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.832 |
SHM01635.1 | SHN14614.1 | SAMN05444387_1708 | SAMN05444387_4317 | Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | Amino acid adenylation domain-containing protein. | 0.414 |
SHM01635.1 | dnaN | SAMN05444387_1708 | SAMN05444387_4708 | Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.566 |
SHM01635.1 | polA | SAMN05444387_1708 | SAMN05444387_2170 | Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.918 |
SHM01635.1 | rnhB | SAMN05444387_1708 | SAMN05444387_3785 | Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.860 |
SHM01635.1 | thyA | SAMN05444387_1708 | SAMN05444387_2019 | Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.666 |
SHM04060.1 | SHM04172.1 | SAMN05444387_1768 | SAMN05444387_1770 | NADH dehydrogenase subunit G. | NADH dehydrogenase subunit E. | 0.999 |
SHM04060.1 | SHN14614.1 | SAMN05444387_1768 | SAMN05444387_4317 | NADH dehydrogenase subunit G. | Amino acid adenylation domain-containing protein. | 0.999 |
SHM04060.1 | nuoF | SAMN05444387_1768 | SAMN05444387_1769 | NADH dehydrogenase subunit G. | NADH dehydrogenase subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. | 0.999 |
SHM04060.1 | rnhB | SAMN05444387_1768 | SAMN05444387_3785 | NADH dehydrogenase subunit G. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.745 |
SHM04172.1 | SHM04060.1 | SAMN05444387_1770 | SAMN05444387_1768 | NADH dehydrogenase subunit E. | NADH dehydrogenase subunit G. | 0.999 |
SHM04172.1 | SHN14614.1 | SAMN05444387_1770 | SAMN05444387_4317 | NADH dehydrogenase subunit E. | Amino acid adenylation domain-containing protein. | 0.999 |
SHM04172.1 | nuoF | SAMN05444387_1770 | SAMN05444387_1769 | NADH dehydrogenase subunit E. | NADH dehydrogenase subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. | 0.999 |
SHM04172.1 | rnhB | SAMN05444387_1770 | SAMN05444387_3785 | NADH dehydrogenase subunit E. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.734 |
SHM12316.1 | rnhB | SAMN05444387_1976 | SAMN05444387_3785 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.834 |
SHN14614.1 | SHM01635.1 | SAMN05444387_4317 | SAMN05444387_1708 | Amino acid adenylation domain-containing protein. | Ribonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.414 |
SHN14614.1 | SHM04060.1 | SAMN05444387_4317 | SAMN05444387_1768 | Amino acid adenylation domain-containing protein. | NADH dehydrogenase subunit G. | 0.999 |
SHN14614.1 | SHM04172.1 | SAMN05444387_4317 | SAMN05444387_1770 | Amino acid adenylation domain-containing protein. | NADH dehydrogenase subunit E. | 0.999 |