STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHL51007.15-methyltetrahydrofolate--homocysteine methyltransferase. (356 aa)    
Predicted Functional Partners:
SHL51075.1
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
 
 0.999
SHL51142.1
5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.995
SHL50344.1
O-acetylhomoserine sulfhydrylase.
  
 
 0.962
SHL77233.1
Sulfite reductase (NADPH) flavoprotein alpha-component.
  
 0.952
SHL50368.1
Homoserine dehydrogenase.
  
 
 0.943
SHL50437.1
Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family.
  
 
 0.943
SHL50475.1
Aspartate kinase.
  
 
 0.943
metE
Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.943
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 
 0.938
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.937
Your Current Organism:
Flavobacterium saccharophilum
NCBI taxonomy Id: 29534
Other names: ATCC 49530, CIP 104743, Cytophaga saccharophila, F. saccharophilum, IFO 15944, JCM 8520, LMG 8384, LMG:8384, NBRC 15944, NCIMB 2072, strain 024 Agbo and Moss
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