node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHL50368.1 | SHL50437.1 | SAMN05444366_0938 | SAMN05444366_0940 | Homoserine dehydrogenase. | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | 0.998 |
SHL50368.1 | SHL86931.1 | SAMN05444366_0938 | SAMN05444366_1854 | Homoserine dehydrogenase. | Cystathionine beta-synthase. | 0.823 |
SHL50368.1 | SHL88063.1 | SAMN05444366_0938 | SAMN05444366_1896 | Homoserine dehydrogenase. | Serine O-acetyltransferase. | 0.858 |
SHL50368.1 | SHM10844.1 | SAMN05444366_0938 | SAMN05444366_2375 | Homoserine dehydrogenase. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.815 |
SHL50368.1 | SHM72363.1 | SAMN05444366_0938 | SAMN05444366_3914 | Homoserine dehydrogenase. | Cystathionine beta-synthase. | 0.944 |
SHL50368.1 | SHM78940.1 | SAMN05444366_0938 | SAMN05444366_4175 | Homoserine dehydrogenase. | Phosphoserine phosphatase. | 0.957 |
SHL50368.1 | glyA | SAMN05444366_0938 | SAMN05444366_1655 | Homoserine dehydrogenase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.870 |
SHL50368.1 | ilvA | SAMN05444366_0938 | SAMN05444366_3938 | Homoserine dehydrogenase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.949 |
SHL50368.1 | thrB | SAMN05444366_0938 | SAMN05444366_1830 | Homoserine dehydrogenase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.996 |
SHL50368.1 | trpA | SAMN05444366_0938 | SAMN05444366_2559 | Homoserine dehydrogenase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.914 |
SHL50437.1 | SHL50368.1 | SAMN05444366_0940 | SAMN05444366_0938 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Homoserine dehydrogenase. | 0.998 |
SHL50437.1 | SHL86931.1 | SAMN05444366_0940 | SAMN05444366_1854 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Cystathionine beta-synthase. | 0.823 |
SHL50437.1 | SHL88063.1 | SAMN05444366_0940 | SAMN05444366_1896 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Serine O-acetyltransferase. | 0.880 |
SHL50437.1 | SHM10844.1 | SAMN05444366_0940 | SAMN05444366_2375 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.815 |
SHL50437.1 | SHM72363.1 | SAMN05444366_0940 | SAMN05444366_3914 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Cystathionine beta-synthase. | 0.944 |
SHL50437.1 | SHM78940.1 | SAMN05444366_0940 | SAMN05444366_4175 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Phosphoserine phosphatase. | 0.957 |
SHL50437.1 | glyA | SAMN05444366_0940 | SAMN05444366_1655 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.870 |
SHL50437.1 | ilvA | SAMN05444366_0940 | SAMN05444366_3938 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.949 |
SHL50437.1 | thrB | SAMN05444366_0940 | SAMN05444366_1830 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.991 |
SHL50437.1 | trpA | SAMN05444366_0940 | SAMN05444366_2559 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.914 |