SEH12311.1 protein (Thermoleophilum album) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

SEH12311.1

3-hydroxybutyryl-CoA dehydrogenase. (293 aa)

Predicted Functional Partners:

SEH12315.1

0.991

SEH13778.1

0.958

SEH15512.1

0.947

SEH13856.1

0.946

SEH10198.1

0.943

SEH13828.1

0.942

SEH12050.1

0.934

SEH15852.1

0.919

SEH13860.1

0.894

SEH12486.1

0.873

Your Current Organism:

Thermoleophilum album

NCBI taxonomy Id: 29539
Other names: ATCC 35263, T. album, Thermoleiphilum album, strain HS-5

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SEH10198.1	SEH12311.1	SAMN02745716_0045	SAMN02745716_1050	enoyl-CoA hydratase.	3-hydroxybutyryl-CoA dehydrogenase.	0.943
SEH10198.1	SEH12315.1	SAMN02745716_0045	SAMN02745716_1051	enoyl-CoA hydratase.	Enoyl-CoA hydratase/carnithine racemase.	0.455
SEH10198.1	SEH12486.1	SAMN02745716_0045	SAMN02745716_1106	enoyl-CoA hydratase.	acetyl-CoA acetyltransferases; Belongs to the thiolase-like superfamily. Thiolase family.	0.774
SEH10198.1	SEH13828.1	SAMN02745716_0045	SAMN02745716_1343	enoyl-CoA hydratase.	2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase.	0.820
SEH10198.1	SEH13860.1	SAMN02745716_0045	SAMN02745716_1361	enoyl-CoA hydratase.	3-oxoadipyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.774
SEH10198.1	SEH15852.1	SAMN02745716_0045	SAMN02745716_2086	enoyl-CoA hydratase.	acetyl-CoA C-acetyltransferase.	0.979
SEH12050.1	SEH12311.1	SAMN02745716_0966	SAMN02745716_1050	Enoyl-CoA hydratase/carnithine racemase.	3-hydroxybutyryl-CoA dehydrogenase.	0.934
SEH12050.1	SEH12315.1	SAMN02745716_0966	SAMN02745716_1051	Enoyl-CoA hydratase/carnithine racemase.	Enoyl-CoA hydratase/carnithine racemase.	0.436
SEH12050.1	SEH12486.1	SAMN02745716_0966	SAMN02745716_1106	Enoyl-CoA hydratase/carnithine racemase.	acetyl-CoA acetyltransferases; Belongs to the thiolase-like superfamily. Thiolase family.	0.774
SEH12050.1	SEH13828.1	SAMN02745716_0966	SAMN02745716_1343	Enoyl-CoA hydratase/carnithine racemase.	2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase.	0.434
SEH12050.1	SEH13860.1	SAMN02745716_0966	SAMN02745716_1361	Enoyl-CoA hydratase/carnithine racemase.	3-oxoadipyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.774
SEH12050.1	SEH15852.1	SAMN02745716_0966	SAMN02745716_2086	Enoyl-CoA hydratase/carnithine racemase.	acetyl-CoA C-acetyltransferase.	0.911
SEH12311.1	SEH10198.1	SAMN02745716_1050	SAMN02745716_0045	3-hydroxybutyryl-CoA dehydrogenase.	enoyl-CoA hydratase.	0.943
SEH12311.1	SEH12050.1	SAMN02745716_1050	SAMN02745716_0966	3-hydroxybutyryl-CoA dehydrogenase.	Enoyl-CoA hydratase/carnithine racemase.	0.934
SEH12311.1	SEH12315.1	SAMN02745716_1050	SAMN02745716_1051	3-hydroxybutyryl-CoA dehydrogenase.	Enoyl-CoA hydratase/carnithine racemase.	0.991
SEH12311.1	SEH12486.1	SAMN02745716_1050	SAMN02745716_1106	3-hydroxybutyryl-CoA dehydrogenase.	acetyl-CoA acetyltransferases; Belongs to the thiolase-like superfamily. Thiolase family.	0.873
SEH12311.1	SEH13778.1	SAMN02745716_1050	SAMN02745716_1313	3-hydroxybutyryl-CoA dehydrogenase.	Enoyl-CoA hydratase/carnithine racemase.	0.958
SEH12311.1	SEH13828.1	SAMN02745716_1050	SAMN02745716_1343	3-hydroxybutyryl-CoA dehydrogenase.	2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase.	0.942
SEH12311.1	SEH13856.1	SAMN02745716_1050	SAMN02745716_1359	3-hydroxybutyryl-CoA dehydrogenase.	enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.946
SEH12311.1	SEH13860.1	SAMN02745716_1050	SAMN02745716_1361	3-hydroxybutyryl-CoA dehydrogenase.	3-oxoadipyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.894

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.932

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006457

Protein folding

8 of 34

2.39

6.77

3.37e-15

GO:0042026

Protein refolding

2 of 2

3.02

1.38

0.0032

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000774

Adenyl-nucleotide exchange factor activity

5 of 5

3.02

5.7

2.78e-11

GO:0051087

Chaperone binding

5 of 6

2.94

5.67

2.78e-11

GO:0042803

Protein homodimerization activity

5 of 7

2.87

5.58

3.49e-11

GO:0005515

Protein binding

9 of 95

1.99

5.31

1.25e-14

GO:0051082

Unfolded protein binding

3 of 24

2.11

2.01

0.00011

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 2580

0.65

0.59

1.03e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:29323202

(2018) Genome-based classification of micromonosporae with a focus on their biotechnological and ecological potential.

5 of 18

2.46

4.82

2.62e-10

PMID:26040993

(2015) A novel salt-tolerant chitobiosidase discovered by genetic screening of a metagenomic library derived from chitin-amended agricultural soil.

2 of 3

2.84

2.15

0.00012

PMID:24706600

(2014) Taxonomic and functional profiles of soil samples from Atlantic forest and Caatinga biomes in northeastern Brazil.

2 of 6

2.54

1.97

0.00022

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1120

Stress response, and Protein folding chaperone

10 of 50

2.32

8.09

1.65e-19

CL:1130

Protein folding

7 of 21

2.54

6.64

4.05e-14

CL:1121

Stress response, and Clp, repeat (R) domain

8 of 40

2.32

6.49

5.99e-15

CL:1131

Protein folding

5 of 16

2.51

4.49

1.74e-09

CL:1162

Protein folding chaperone, and DnaJ C terminal domain

2 of 5

2.62

1.28

0.0047

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00500

Starch and sucrose metabolism

5 of 94

1.74

2.35

2.50e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990220

GroEL-GroES complex

2 of 2

3.02

1.53

0.0017

GOCC:0005737

Cytoplasm

9 of 2107

0.65

0.51

0.0017

GOCC:0005622

Intracellular

10 of 3173

0.52

0.41

0.0017

GOCC:0110165

Cellular anatomical entity

11 of 5566

0.31

0.26

0.0201

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0143

Chaperone

8 of 29

2.46

7.45

1.81e-16

KW-0346

Stress response

8 of 32

2.42

7.33

1.81e-16

KW-0963

Cytoplasm

9 of 264

1.55

3.06

8.02e-12

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01025

GrpE

5 of 5

3.02

5.51

6.61e-11

PF00118

TCP-1/cpn60 chaperonin family

2 of 2

3.02

1.45

0.0024

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013805

GrpE nucleotide exchange factor, coiled-coil

5 of 5

3.02

5.29

1.67e-10

IPR009012

GrpE nucleotide exchange factor, head

5 of 5

3.02

5.29

1.67e-10

IPR000740

GrpE nucleotide exchange factor

5 of 5

3.02

5.29

1.67e-10

IPR027413

GroEL-like equatorial domain superfamily

2 of 2

3.02

1.4

0.0030

IPR027410

TCP-1-like chaperonin intermediate domain superfamily

2 of 2

3.02

1.4

0.0030

(more ...)

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