Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cofEF420-0--gamma-glutamyl ligase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. (260 aa)    
Predicted Functional Partners:
cofD
LPPG:FO 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
 
 
 0.995
mer
Methylenetetrahydromethanopterin reductase; Catalyzes the oxidation of methyl-H(4)MPT to methylene- H(4)MPT.
 
   
 0.973
cofC
2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family.
 
   
 0.804
C481_19280
Lysine biosynthesis protein LysX; COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase).
     
  0.803
cofG
FO synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.
 
   
 0.791
C481_15230
FO synthase subunit 2; COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes.
 
   
 0.776
C481_12789
RimK family alpha-L-glutamate ligase; COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase).
     
  0.765
C481_17457
RimK domain protein ATP-grasp; COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase).
     
  0.765
C481_15915
Luciferase-like protein; COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases.
 
   
 0.760
C481_03757
NADPH-dependent F420 reductase; COG2085 Predicted dinucleotide-binding enzymes.
 
   
 0.756
Your Current Organism:
Natrialba asiatica
NCBI taxonomy Id: 29540
Other names: N. asiatica DSM 12278, Natrialba asiatica 172P1, Natrialba asiatica DSM 12278, halophilic archaebacterium 172P1, halophilic archaeon 172P1, halophilic bacteria (strain 172P1), halophilic bacteria strain 172P1, halophilic bacterium (strain 172P1)
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.