C481_05063 protein (Natrialba asiatica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

C481_05063

Bifunctional UGMP family protein/serine/threonine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family. (568 aa)

Predicted Functional Partners:

C481_18790

0.985

rps24e

0.980

C481_19545

0.979

rps27ae

0.945

eif2g

0.927

infB

0.923

pheS

0.922

C481_05048

0.910

rps6e

0.888

rps15p

0.888

Your Current Organism:

Natrialba asiatica

NCBI taxonomy Id: 29540
Other names: N. asiatica DSM 12278, Natrialba asiatica 172P1, Natrialba asiatica DSM 12278, halophilic archaebacterium 172P1, halophilic archaeon 172P1, halophilic bacteria (strain 172P1), halophilic bacteria strain 172P1, halophilic bacterium (strain 172P1)

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C481_05048	C481_05063	C481_05048	C481_05063	RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; COG0127 Xanthosine triphosphate pyrophosphatase; Belongs to the HAM1 NTPase family.	Bifunctional UGMP family protein/serine/threonine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.	0.910
C481_05048	eif2g	C481_05048	C481_04121	RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; COG0127 Xanthosine triphosphate pyrophosphatase; Belongs to the HAM1 NTPase family.	Translation initiation factor IF-2 subunit gamma; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.	0.449
C481_05048	pheS	C481_05048	C481_19645	RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; COG0127 Xanthosine triphosphate pyrophosphatase; Belongs to the HAM1 NTPase family.	COG0016 Phenylalanyl-tRNA synthetase alpha subunit.	0.596
C481_05048	rps15p	C481_05048	C481_14498	RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; COG0127 Xanthosine triphosphate pyrophosphatase; Belongs to the HAM1 NTPase family.	COG0184 Ribosomal protein S15P/S13E.	0.635
C481_05048	rps24e	C481_05048	C481_05073	RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; COG0127 Xanthosine triphosphate pyrophosphatase; Belongs to the HAM1 NTPase family.	COG2004 Ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family.	0.625
C481_05048	rps27ae	C481_05048	C481_05068	RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; COG0127 Xanthosine triphosphate pyrophosphatase; Belongs to the HAM1 NTPase family.	COG1998 Ribosomal protein S27AE; Belongs to the eukaryotic ribosomal protein eS31 family.	0.487
C481_05063	C481_05048	C481_05063	C481_05048	Bifunctional UGMP family protein/serine/threonine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.	RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; COG0127 Xanthosine triphosphate pyrophosphatase; Belongs to the HAM1 NTPase family.	0.910
C481_05063	C481_18790	C481_05063	C481_18790	Bifunctional UGMP family protein/serine/threonine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.	KEOPS complex Cgi121-like subunit.	0.985
C481_05063	C481_19545	C481_05063	C481_19545	Bifunctional UGMP family protein/serine/threonine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.	Sua5/YciO/YrdC/YwlC family protein; COG0009 Putative translation factor (SUA5).	0.979
C481_05063	eif2g	C481_05063	C481_04121	Bifunctional UGMP family protein/serine/threonine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.	Translation initiation factor IF-2 subunit gamma; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.	0.927
C481_05063	infB	C481_05063	C481_15565	Bifunctional UGMP family protein/serine/threonine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.	Translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.	0.923
C481_05063	pheS	C481_05063	C481_19645	Bifunctional UGMP family protein/serine/threonine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.	COG0016 Phenylalanyl-tRNA synthetase alpha subunit.	0.922
C481_05063	rps15p	C481_05063	C481_14498	Bifunctional UGMP family protein/serine/threonine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.	COG0184 Ribosomal protein S15P/S13E.	0.888
C481_05063	rps24e	C481_05063	C481_05073	Bifunctional UGMP family protein/serine/threonine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.	COG2004 Ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family.	0.980
C481_05063	rps27ae	C481_05063	C481_05068	Bifunctional UGMP family protein/serine/threonine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.	COG1998 Ribosomal protein S27AE; Belongs to the eukaryotic ribosomal protein eS31 family.	0.945
C481_05063	rps6e	C481_05063	C481_04868	Bifunctional UGMP family protein/serine/threonine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.	COG2125 Ribosomal protein S6E (S10); Belongs to the eukaryotic ribosomal protein eS6 family.	0.888
C481_18790	C481_05063	C481_18790	C481_05063	KEOPS complex Cgi121-like subunit.	Bifunctional UGMP family protein/serine/threonine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.	0.985
C481_18790	rps24e	C481_18790	C481_05073	KEOPS complex Cgi121-like subunit.	COG2004 Ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family.	0.456
C481_19545	C481_05063	C481_19545	C481_05063	Sua5/YciO/YrdC/YwlC family protein; COG0009 Putative translation factor (SUA5).	Bifunctional UGMP family protein/serine/threonine protein kinase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.	0.979
C481_19545	infB	C481_19545	C481_15565	Sua5/YciO/YrdC/YwlC family protein; COG0009 Putative translation factor (SUA5).	Translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.	0.400

page 1 of 4

Server load: medium (44%) [HD]

Permalink

Network

Neighborhood

Experiments

Co-occurrence

Databases

Co-expression

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About