| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C481_03077 | C481_04541 | C481_03077 | C481_04541 | Hypothetical protein; COG0262 Dihydrofolate reductase. | COG0307 Riboflavin synthase alpha chain. | 0.847 |
| C481_03077 | C481_06162 | C481_03077 | C481_06162 | Hypothetical protein; COG0262 Dihydrofolate reductase. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | 0.794 |
| C481_03077 | ribH | C481_03077 | C481_12119 | Hypothetical protein; COG0262 Dihydrofolate reductase. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.693 |
| C481_04541 | C481_03077 | C481_04541 | C481_03077 | COG0307 Riboflavin synthase alpha chain. | Hypothetical protein; COG0262 Dihydrofolate reductase. | 0.847 |
| C481_04541 | C481_06162 | C481_04541 | C481_06162 | COG0307 Riboflavin synthase alpha chain. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | 0.990 |
| C481_04541 | C481_10720 | C481_04541 | C481_10720 | COG0307 Riboflavin synthase alpha chain. | Bifunctional deaminase-reductase domain-containing protein; COG0262 Dihydrofolate reductase. | 0.847 |
| C481_04541 | C481_12959 | C481_04541 | C481_12959 | COG0307 Riboflavin synthase alpha chain. | COG1985 Pyrimidine reductase, riboflavin biosynthesis. | 0.972 |
| C481_04541 | ribH | C481_04541 | C481_12119 | COG0307 Riboflavin synthase alpha chain. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.999 |
| C481_04541 | ribK | C481_04541 | C481_06157 | COG0307 Riboflavin synthase alpha chain. | CTP-dependent riboflavin kinase; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. | 0.940 |
| C481_05955 | C481_06162 | C481_05955 | C481_06162 | COG0440 Acetolactate synthase, small (regulatory) subunit. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | 0.643 |
| C481_06162 | C481_03077 | C481_06162 | C481_03077 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | Hypothetical protein; COG0262 Dihydrofolate reductase. | 0.794 |
| C481_06162 | C481_04541 | C481_06162 | C481_04541 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | COG0307 Riboflavin synthase alpha chain. | 0.990 |
| C481_06162 | C481_05955 | C481_06162 | C481_05955 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.643 |
| C481_06162 | C481_10720 | C481_06162 | C481_10720 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | Bifunctional deaminase-reductase domain-containing protein; COG0262 Dihydrofolate reductase. | 0.794 |
| C481_06162 | C481_12959 | C481_06162 | C481_12959 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | COG1985 Pyrimidine reductase, riboflavin biosynthesis. | 0.944 |
| C481_06162 | argS | C481_06162 | C481_04631 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | COG0018 Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.652 |
| C481_06162 | ribH | C481_06162 | C481_12119 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.999 |
| C481_06162 | ribK | C481_06162 | C481_06157 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | CTP-dependent riboflavin kinase; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. | 0.902 |
| C481_06162 | rps2P | C481_06162 | C481_06731 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | COG0052 Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. | 0.698 |
| C481_06162 | taw1 | C481_06162 | C481_06152 | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | tRNA-modifying enzyme; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). | 0.763 |