node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C481_05925 | C481_05955 | C481_05925 | C481_05955 | COG0473 Isocitrate/isopropylmalate dehydrogenase. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.972 |
C481_05925 | C481_05965 | C481_05925 | C481_05965 | COG0473 Isocitrate/isopropylmalate dehydrogenase. | Pyruvate carboxyltransferase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. | 0.936 |
C481_05925 | C481_07466 | C481_05925 | C481_07466 | COG0473 Isocitrate/isopropylmalate dehydrogenase. | Thiamine pyrophosphate protein central region; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | 0.810 |
C481_05925 | C481_07621 | C481_05925 | C481_07621 | COG0473 Isocitrate/isopropylmalate dehydrogenase. | (R)-citramalate synthase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.918 |
C481_05925 | C481_18500 | C481_05925 | C481_18500 | COG0473 Isocitrate/isopropylmalate dehydrogenase. | COG1171 Threonine dehydratase. | 0.789 |
C481_05925 | C481_19795 | C481_05925 | C481_19795 | COG0473 Isocitrate/isopropylmalate dehydrogenase. | Branched-chain alpha-keto acid dehydrogenase subunit E2; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. | 0.846 |
C481_05925 | ilvC | C481_05925 | C481_05950 | COG0473 Isocitrate/isopropylmalate dehydrogenase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.944 |
C481_05925 | ilvD | C481_05925 | C481_07986 | COG0473 Isocitrate/isopropylmalate dehydrogenase. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.898 |
C481_05955 | C481_05925 | C481_05955 | C481_05925 | COG0440 Acetolactate synthase, small (regulatory) subunit. | COG0473 Isocitrate/isopropylmalate dehydrogenase. | 0.972 |
C481_05955 | C481_05965 | C481_05955 | C481_05965 | COG0440 Acetolactate synthase, small (regulatory) subunit. | Pyruvate carboxyltransferase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. | 0.958 |
C481_05955 | C481_07466 | C481_05955 | C481_07466 | COG0440 Acetolactate synthase, small (regulatory) subunit. | Thiamine pyrophosphate protein central region; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | 0.989 |
C481_05955 | C481_07621 | C481_05955 | C481_07621 | COG0440 Acetolactate synthase, small (regulatory) subunit. | (R)-citramalate synthase; COG0119 Isopropylmalate/homocitrate/citramalate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.937 |
C481_05955 | C481_07726 | C481_05955 | C481_07726 | COG0440 Acetolactate synthase, small (regulatory) subunit. | COG0281 Malic enzyme. | 0.881 |
C481_05955 | C481_18500 | C481_05955 | C481_18500 | COG0440 Acetolactate synthase, small (regulatory) subunit. | COG1171 Threonine dehydratase. | 0.955 |
C481_05955 | C481_19795 | C481_05955 | C481_19795 | COG0440 Acetolactate synthase, small (regulatory) subunit. | Branched-chain alpha-keto acid dehydrogenase subunit E2; COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. | 0.897 |
C481_05955 | ilvC | C481_05955 | C481_05950 | COG0440 Acetolactate synthase, small (regulatory) subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
C481_05955 | ilvD | C481_05955 | C481_07986 | COG0440 Acetolactate synthase, small (regulatory) subunit. | COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.953 |
C481_05965 | C481_05925 | C481_05965 | C481_05925 | Pyruvate carboxyltransferase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. | COG0473 Isocitrate/isopropylmalate dehydrogenase. | 0.936 |
C481_05965 | C481_05955 | C481_05965 | C481_05955 | Pyruvate carboxyltransferase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. | COG0440 Acetolactate synthase, small (regulatory) subunit. | 0.958 |
C481_05965 | C481_07466 | C481_05965 | C481_07466 | Pyruvate carboxyltransferase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. | Thiamine pyrophosphate protein central region; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. | 0.848 |