Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
C481_09417COG2524 Predicted transcriptional regulator, contains C-terminal CBS domains. (177 aa)    
Predicted Functional Partners:
C481_18615
COG3365 Uncharacterized protein conserved in archaea.
  
     0.741
cofC
2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family.
  
     0.739
C481_13979
Regulatory protein Crp; COG1497 Predicted transcriptional regulator.
  
     0.720
C481_13944
COG2061 ACT-domain-containing protein, predicted allosteric regulator of homoserine dehydrogenase.
  
     0.708
C481_08006
Phosphoesterase RecJ domain-containing protein; COG1107 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain.
  
     0.694
C481_08021
Dihydropyrimidine dehydrogenase; COG0042 tRNA-dihydrouridine synthase.
  
     0.690
tfe
Transcription factor TFIIE subunit alpha; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation [...]
  
     0.690
C481_19100
Hypothetical protein.
  
     0.690
C481_11919
COG1885 Uncharacterized protein conserved in archaea; Belongs to the UPF0212 family.
  
     0.682
C481_09962
Hypothetical protein; COG0517 FOG: CBS domain.
   
    0.680
Your Current Organism:
Natrialba asiatica
NCBI taxonomy Id: 29540
Other names: N. asiatica DSM 12278, Natrialba asiatica 172P1, Natrialba asiatica DSM 12278, halophilic archaebacterium 172P1, halophilic archaeon 172P1, halophilic bacteria (strain 172P1), halophilic bacteria strain 172P1, halophilic bacterium (strain 172P1)
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