| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C481_15705 | C481_15710 | C481_15705 | C481_15710 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | COG0015 Adenylosuccinate lyase. | 0.992 |
| C481_15705 | C481_20736 | C481_15705 | C481_20736 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | 3-carboxy-cis,cis-muconate cycloisomerase; COG0015 Adenylosuccinate lyase. | 0.985 |
| C481_15705 | folD | C481_15705 | C481_13434 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.991 |
| C481_15705 | guaB | C481_15705 | C481_08451 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.990 |
| C481_15705 | purC | C481_15705 | C481_15235 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family. | 0.986 |
| C481_15705 | purD | C481_15705 | C481_13394 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | COG0151 Phosphoribosylamine-glycine ligase; Belongs to the GARS family. | 0.999 |
| C481_15705 | purF | C481_15705 | C481_08828 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.997 |
| C481_15705 | purL | C481_15705 | C481_10695 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.996 |
| C481_15705 | purQ | C481_15705 | C481_15265 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.996 |
| C481_15705 | purS | C481_15705 | C481_15260 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Phosphoribosylformylglycinamidine synthase subunit PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] | 0.990 |
| C481_15710 | C481_15705 | C481_15710 | C481_15705 | COG0015 Adenylosuccinate lyase. | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | 0.992 |
| C481_15710 | folD | C481_15710 | C481_13434 | COG0015 Adenylosuccinate lyase. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.538 |
| C481_15710 | guaB | C481_15710 | C481_08451 | COG0015 Adenylosuccinate lyase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.887 |
| C481_15710 | purC | C481_15710 | C481_15235 | COG0015 Adenylosuccinate lyase. | COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family. | 0.994 |
| C481_15710 | purD | C481_15710 | C481_13394 | COG0015 Adenylosuccinate lyase. | COG0151 Phosphoribosylamine-glycine ligase; Belongs to the GARS family. | 0.984 |
| C481_15710 | purF | C481_15710 | C481_08828 | COG0015 Adenylosuccinate lyase. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.976 |
| C481_15710 | purL | C481_15710 | C481_10695 | COG0015 Adenylosuccinate lyase. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.919 |
| C481_15710 | purQ | C481_15710 | C481_15265 | COG0015 Adenylosuccinate lyase. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.900 |
| C481_15710 | purS | C481_15710 | C481_15260 | COG0015 Adenylosuccinate lyase. | Phosphoribosylformylglycinamidine synthase subunit PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] | 0.937 |
| C481_20736 | C481_15705 | C481_20736 | C481_15705 | 3-carboxy-cis,cis-muconate cycloisomerase; COG0015 Adenylosuccinate lyase. | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | 0.985 |