STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ligNAD(+)-dependent DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (681 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.935
exo
COG0258 5'-3' exonuclease (including N-terminal domain of PolI) [DNA replication, recombination, and repair].
     
 0.856
leuS
COG0495 Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
 
 0.854
cbiQ
COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism].
       0.824
cbiO2
Cobalt import ATP-binding protein CbiO2; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
       0.807
cbiO1
Cobalt import ATP-binding protein cbiO1; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
       0.807
BAP39330.1
Predicted transmembrane protein.
       0.650
uvrD
COG0210 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair].
  
  
 0.605
BAP39331.1
Predicted transmembrane protein.
       0.588
dnaE
COG0587 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair].
     
 0.525
Your Current Organism:
Mycoplasma canadense
NCBI taxonomy Id: 29554
Other names: ATCC 29418, M. canadense, Metamycoplasma canadense, NCTC 10152, strain 275C
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