KDE43022.1 protein (Mycoplasma hyosynoviae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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Experiments

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Score

KDE43022.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (312 aa)

Predicted Functional Partners:

KDE43019.1

0.797

KDE43020.1

0.787

KDE43021.1

0.787

KDE43004.1

0.778

KDE43003.1

0.773

KDE43018.1

0.513

Your Current Organism:

Mycoplasma hyosynoviae

NCBI taxonomy Id: 29559
Other names: ATCC 25591, M. hyosynoviae, Metamycoplasma hyosynoviae, Mycoplasma suidaniae, NCTC 10167, strain S-16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KDE43003.1	KDE43004.1	NPL3_00445	NPL3_00450	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.834
KDE43003.1	KDE43018.1	NPL3_00445	NPL3_00440	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.513
KDE43003.1	KDE43019.1	NPL3_00445	NPL3_00455	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.824
KDE43003.1	KDE43020.1	NPL3_00445	NPL3_00460	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.917
KDE43003.1	KDE43021.1	NPL3_00445	NPL3_00465	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.917
KDE43003.1	KDE43022.1	NPL3_00445	NPL3_00470	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.773
KDE43004.1	KDE43003.1	NPL3_00450	NPL3_00445	DNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.834
KDE43004.1	KDE43018.1	NPL3_00450	NPL3_00440	DNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.513
KDE43004.1	KDE43019.1	NPL3_00450	NPL3_00455	DNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.786
KDE43004.1	KDE43020.1	NPL3_00450	NPL3_00460	DNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.785
KDE43004.1	KDE43021.1	NPL3_00450	NPL3_00465	DNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.829
KDE43004.1	KDE43022.1	NPL3_00450	NPL3_00470	DNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.778
KDE43018.1	KDE43003.1	NPL3_00440	NPL3_00445	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.513
KDE43018.1	KDE43004.1	NPL3_00440	NPL3_00450	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	DNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.513
KDE43018.1	KDE43019.1	NPL3_00440	NPL3_00455	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.513
KDE43018.1	KDE43020.1	NPL3_00440	NPL3_00460	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.513
KDE43018.1	KDE43021.1	NPL3_00440	NPL3_00465	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.513
KDE43018.1	KDE43022.1	NPL3_00440	NPL3_00470	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.513
KDE43019.1	KDE43003.1	NPL3_00455	NPL3_00445	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.824
KDE43019.1	KDE43004.1	NPL3_00455	NPL3_00450	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	DNA methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.786

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.9

expected number of edges:

16

PPI enrichment p-value:

2.33e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006289

Nucleotide-excision repair

4 of 34

2.37

2.64

8.50e-06

GO:0000724

Double-strand break repair via homologous recombination

4 of 109

1.86

1.66

0.00036

GO:0007004

Telomere maintenance via telomerase

2 of 7

2.75

1.47

0.0021

GO:0006281

DNA repair

5 of 369

1.43

1.34

0.00042

GO:0007049

Cell cycle

5 of 401

1.39

1.29

0.00047

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003684

Damaged DNA binding

3 of 32

2.27

1.62

0.00089

GO:0003697

Single-stranded DNA binding

3 of 39

2.19

1.6

0.00089

GO:0043047

Single-stranded telomeric DNA binding

2 of 6

2.82

1.38

0.0031

GO:0019888

Protein phosphatase regulator activity

2 of 25

2.2

0.96

0.0166

GO:0003677

DNA binding

6 of 1361

0.94

0.68

0.0060

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005662

DNA replication factor A complex

3 of 3

3.3

3.22

1.48e-06

GO:0000228

Nuclear chromosome

4 of 119

1.83

1.99

4.75e-05

GO:0000159

Protein phosphatase type 2A complex

2 of 5

2.9

1.88

0.00038

GO:0000781

Chromosome, telomeric region

2 of 39

2.01

1.12

0.0073

GO:0140513

Nuclear protein-containing complex

5 of 689

1.16

1.02

0.00075

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14873

Mixed, incl. DNA damage checkpoint signaling, and HDR through Single Strand Annealing (SSA)

5 of 42

2.37

3.79

3.25e-08

CL:14945

RecQ family helicase-topoisomerase III complex, and DNA replication factor A complex

3 of 5

3.08

3.41

6.03e-07

CL:14812

DNA-templated DNA replication, and HDR through Single Strand Annealing (SSA)

6 of 194

1.79

2.88

7.75e-08

CL:3535

CTLA4 inhibitory signaling, and Serine esterase

2 of 6

2.82

1.74

0.00069

CL:14894

Mixed, incl. Replication factor A protein-like, and Single-stranded DNA helicase activity

2 of 6

2.82

1.74

0.00069

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03420

Nucleotide excision repair

7 of 299

1.67

2.94

4.48e-09

map03430

Mismatch repair

6 of 286

1.62

2.47

1.71e-07

map03030

DNA replication

6 of 328

1.56

2.31

2.55e-07

map03440

Homologous recombination

6 of 452

1.42

1.9

1.26e-06

map03015

mRNA surveillance pathway

2 of 107

1.57

0.7

0.0385

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5696395

Formation of Incision Complex in GG-NER

3 of 20

2.48

2.2

7.72e-05

MAP-5358606

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

2 of 7

2.75

1.66

0.00096

MAP-69273

Cyclin A/B1/B2 associated events during G2/M transition

2 of 10

2.6

1.64

0.00096

MAP-6783310

Fanconi Anemia Pathway

2 of 14

2.45

1.58

0.0012

MAP-5358565

Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)

2 of 13

2.49

1.58

0.0012

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005662

DNA replication factor A complex

2 of 4

3.0

1.38

0.0032

GOCC:0000159

Protein phosphatase type 2A complex

2 of 5

2.9

1.38

0.0032

GOCC:0005963

Magnesium-dependent protein serine/threonine phosphatase complex

2 of 7

2.75

1.37

0.0032

GOCC:0000228

Nuclear chromosome

3 of 181

1.52

0.95

0.0090

GOCC:0031981

Nuclear lumen

4 of 708

1.05

0.62

0.0221

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01336

OB-fold nucleic acid binding domain

2 of 7

2.75

1.17

0.0074

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR040260

Replication factor A protein-like

2 of 2

3.3

1.36

0.0036

IPR012340

Nucleic acid-binding, OB-fold

3 of 57

2.02

1.24

0.0041

IPR004365

OB-fold nucleic acid binding domain, AA-tRNA synthetase-type

2 of 7

2.75

1.18

0.0072

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