node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHM03538.1 | SHM09884.1 | SAMN05878437_0894 | SAMN05878437_1208 | Acyl transferase domain-containing protein. | PAS domain S-box-containing protein. | 0.950 |
SHM03538.1 | birA | SAMN05878437_0894 | SAMN05878437_1649 | Acyl transferase domain-containing protein. | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.745 |
SHM03538.1 | dapF | SAMN05878437_0894 | SAMN05878437_1840 | Acyl transferase domain-containing protein. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.564 |
SHM03538.1 | guaB | SAMN05878437_0894 | SAMN05878437_2574 | Acyl transferase domain-containing protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.757 |
SHM03538.1 | nadE | SAMN05878437_0894 | SAMN05878437_1522 | Acyl transferase domain-containing protein. | NAD+ synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.901 |
SHM03538.1 | nnrD | SAMN05878437_0894 | SAMN05878437_0679 | Acyl transferase domain-containing protein. | NAD(P)H-hydrate epimerase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of bot [...] | 0.686 |
SHM03538.1 | rnr | SAMN05878437_0894 | SAMN05878437_0987 | Acyl transferase domain-containing protein. | RNAse R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.447 |
SHM03538.1 | rppH | SAMN05878437_0894 | SAMN05878437_0963 | Acyl transferase domain-containing protein. | Putative (di)nucleoside polyphosphate hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.869 |
SHM04937.1 | SHM09884.1 | SAMN05878437_0962 | SAMN05878437_1208 | PTSINtr with GAF domain, PtsP; Belongs to the PEP-utilizing enzyme family. | PAS domain S-box-containing protein. | 0.740 |
SHM04937.1 | rppH | SAMN05878437_0962 | SAMN05878437_0963 | PTSINtr with GAF domain, PtsP; Belongs to the PEP-utilizing enzyme family. | Putative (di)nucleoside polyphosphate hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.863 |
SHM09884.1 | SHM03538.1 | SAMN05878437_1208 | SAMN05878437_0894 | PAS domain S-box-containing protein. | Acyl transferase domain-containing protein. | 0.950 |
SHM09884.1 | SHM04937.1 | SAMN05878437_1208 | SAMN05878437_0962 | PAS domain S-box-containing protein. | PTSINtr with GAF domain, PtsP; Belongs to the PEP-utilizing enzyme family. | 0.740 |
SHM09884.1 | birA | SAMN05878437_1208 | SAMN05878437_1649 | PAS domain S-box-containing protein. | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.534 |
SHM09884.1 | guaB | SAMN05878437_1208 | SAMN05878437_2574 | PAS domain S-box-containing protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.858 |
SHM09884.1 | nadE | SAMN05878437_1208 | SAMN05878437_1522 | PAS domain S-box-containing protein. | NAD+ synthase (glutamine-hydrolysing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.621 |
SHM09884.1 | rppH | SAMN05878437_1208 | SAMN05878437_0963 | PAS domain S-box-containing protein. | Putative (di)nucleoside polyphosphate hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.821 |
birA | SHM03538.1 | SAMN05878437_1649 | SAMN05878437_0894 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Acyl transferase domain-containing protein. | 0.745 |
birA | SHM09884.1 | SAMN05878437_1649 | SAMN05878437_1208 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | PAS domain S-box-containing protein. | 0.534 |
birA | dapF | SAMN05878437_1649 | SAMN05878437_1840 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.549 |
birA | guaB | SAMN05878437_1649 | SAMN05878437_2574 | Bifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.719 |