ZOSMA_55G00060 protein (Zostera marina) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

ZOSMA_55G00060

TLC domain-containing protein. (309 aa)

Predicted Functional Partners:

ZOSMA_8G01130

0.891

A0A0K9PLQ0

0.879

ZOSMA_46G00660

0.836

ZOSMA_2G02590

0.816

ZOSMA_20G01280

0.816

ZOSMA_8G00900

0.811

ZOSMA_67G00550

0.754

ZOSMA_2G01050

0.754

A0A0K9Q2P9

0.754

ZOSMA_93G00540

0.734

Your Current Organism:

Zostera marina

NCBI taxonomy Id: 29655
Other names: Z. marina, Zostera marina L.

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0K9PLQ0	A0A0K9Q2P9	A0A0K9PLQ0	A0A0K9Q2P9	Ceramide kinase.	3-ketodihydrosphinganine reductase.	0.769
A0A0K9PLQ0	ZOSMA_20G01280	A0A0K9PLQ0	A0A0K9PN68	Ceramide kinase.	Sphingobase C4-Hydroxylase; Belongs to the sterol desaturase family.	0.638
A0A0K9PLQ0	ZOSMA_2G01050	A0A0K9PLQ0	A0A0K9PAI2	Ceramide kinase.	3-ketodihydrosphinganine reductase.	0.769
A0A0K9PLQ0	ZOSMA_2G02590	A0A0K9PLQ0	A0A0K9PBB5	Ceramide kinase.	Sphingobase C4-Hydroxylase; Belongs to the sterol desaturase family.	0.598
A0A0K9PLQ0	ZOSMA_46G00660	A0A0K9PLQ0	A0A0K9P2E9	Ceramide kinase.	Long Chain Base 1-Phosphate Phosphatase.	0.598
A0A0K9PLQ0	ZOSMA_55G00060	A0A0K9PLQ0	A0A0K9NY29	Ceramide kinase.	TLC domain-containing protein.	0.879
A0A0K9PLQ0	ZOSMA_67G00550	A0A0K9PLQ0	A0A0K9NU23	Ceramide kinase.	3-ketodihydrosphinganine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.769
A0A0K9PLQ0	ZOSMA_8G00900	A0A0K9PLQ0	A0A0K9NLT8	Ceramide kinase.	UDP-Glc: ceramide beta-glucosyltransferase, family GT21.	0.914
A0A0K9PLQ0	ZOSMA_8G01130	A0A0K9PLQ0	A0A0K9NLJ6	Ceramide kinase.	Sphingolipid delta(4)-desaturase DES1-like; Sphingolipid-delta-4-desaturase required for the biosynthesis of delta-4-unsaturated sphingolipids and derivatives.	0.904
A0A0K9PLQ0	ZOSMA_93G00540	A0A0K9PLQ0	A0A0K9NKU7	Ceramide kinase.	Alkaline phytoceramidase.	0.917
A0A0K9Q2P9	A0A0K9PLQ0	A0A0K9Q2P9	A0A0K9PLQ0	3-ketodihydrosphinganine reductase.	Ceramide kinase.	0.769
A0A0K9Q2P9	ZOSMA_20G01280	A0A0K9Q2P9	A0A0K9PN68	3-ketodihydrosphinganine reductase.	Sphingobase C4-Hydroxylase; Belongs to the sterol desaturase family.	0.838
A0A0K9Q2P9	ZOSMA_2G02590	A0A0K9Q2P9	A0A0K9PBB5	3-ketodihydrosphinganine reductase.	Sphingobase C4-Hydroxylase; Belongs to the sterol desaturase family.	0.838
A0A0K9Q2P9	ZOSMA_46G00660	A0A0K9Q2P9	A0A0K9P2E9	3-ketodihydrosphinganine reductase.	Long Chain Base 1-Phosphate Phosphatase.	0.863
A0A0K9Q2P9	ZOSMA_55G00060	A0A0K9Q2P9	A0A0K9NY29	3-ketodihydrosphinganine reductase.	TLC domain-containing protein.	0.754
A0A0K9Q2P9	ZOSMA_8G01130	A0A0K9Q2P9	A0A0K9NLJ6	3-ketodihydrosphinganine reductase.	Sphingolipid delta(4)-desaturase DES1-like; Sphingolipid-delta-4-desaturase required for the biosynthesis of delta-4-unsaturated sphingolipids and derivatives.	0.870
A0A0K9Q2P9	ZOSMA_93G00540	A0A0K9Q2P9	A0A0K9NKU7	3-ketodihydrosphinganine reductase.	Alkaline phytoceramidase.	0.758
ZOSMA_20G01280	A0A0K9PLQ0	A0A0K9PN68	A0A0K9PLQ0	Sphingobase C4-Hydroxylase; Belongs to the sterol desaturase family.	Ceramide kinase.	0.638
ZOSMA_20G01280	A0A0K9Q2P9	A0A0K9PN68	A0A0K9Q2P9	Sphingobase C4-Hydroxylase; Belongs to the sterol desaturase family.	3-ketodihydrosphinganine reductase.	0.838
ZOSMA_20G01280	ZOSMA_2G01050	A0A0K9PN68	A0A0K9PAI2	Sphingobase C4-Hydroxylase; Belongs to the sterol desaturase family.	3-ketodihydrosphinganine reductase.	0.838

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Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.894

expected number of edges:

92

PPI enrichment p-value:

1

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

7 of 102

1.21

1.35

1.90e-05

GO:0010467

Gene expression

9 of 179

1.08

1.23

2.28e-06

GO:0009059

Macromolecule biosynthetic process

9 of 199

1.03

1.15

2.84e-06

GO:0031564

Transcription antitermination

2 of 4

2.07

1.04

0.0109

GO:0006353

DNA-templated transcription, termination

2 of 6

1.9

0.92

0.0174

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003743

Translation initiation factor activity

3 of 5

2.15

1.66

0.00063

GO:0003924

GTPase activity

3 of 17

1.62

1.12

0.0042

GO:0003723

RNA binding

6 of 94

1.18

1.06

0.00059

GO:0019843

rRNA binding

4 of 42

1.35

1.01

0.0034

GO:0003735

Structural constituent of ribosome

4 of 58

1.21

0.88

0.0051

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

4 of 64

1.17

0.74

0.0129

GO:0005622

Intracellular anatomical structure

10 of 900

0.42

0.31

0.0129

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:277

Mixed, incl. Ribosome biogenesis, and Transcription termination

4 of 6

2.2

2.84

2.02e-06

CL:102

Structural constituent of ribosome, and Transcription, DNA-templated

10 of 108

1.34

2.22

1.46e-10

CL:105

Structural constituent of ribosome, and Proton channel activity

9 of 92

1.36

2.22

7.95e-10

CL:125

Structural constituent of ribosome

4 of 40

1.37

1.2

0.00087

CL:112

Structural constituent of ribosome

5 of 72

1.22

1.13

0.00041

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ane03010

Ribosome

4 of 50

1.28

0.97

0.0033

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0694

RNA-binding

5 of 54

1.34

1.28

0.00033

KW-0699

rRNA-binding

4 of 36

1.42

1.2

0.0012

KW-0689

Ribosomal protein

4 of 56

1.23

0.91

0.0040

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