AWRI3580_g3619 protein (Hanseniaspora uvarum)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AWRI3580_g3619

U3 small nucleolar RNA-associated protein 14. (938 aa)

Predicted Functional Partners:

AWRI3580_g878

0.999

AWRI3580_g2916

0.998

AWRI3580_g2306

0.998

AWRI3580_g1759

0.998

AWRI3580_g1278

0.998

AWRI3580_g1219

0.998

AWRI3580_g450

0.998

AWRI3580_g2913

0.997

AWRI3580_g1024

0.997

AWRI3580_g584

0.997

Your Current Organism:

Hanseniaspora uvarum

NCBI taxonomy Id: 29833
Other names: ATCC 32369, CBS 314, DBVPG 6718, H. uvarum, Hanseniaspora apiculata, IFO 10833, Kloeckera apiculata, Kloeckeraspora uvarum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AWRI3580_g1024	AWRI3580_g1219	A0A1E5RYA2	A0A1E5RUF2	Protein SOF1.	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	0.998
AWRI3580_g1024	AWRI3580_g1278	A0A1E5RYA2	A0A1E5RUE9	Protein SOF1.	40S ribosomal protein S9-B.	0.998
AWRI3580_g1024	AWRI3580_g1759	A0A1E5RYA2	A0A1E5RR21	Protein SOF1.	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family.	0.998
AWRI3580_g1024	AWRI3580_g2306	A0A1E5RYA2	A0A1E5RPE1	Protein SOF1.	Putative ATP-dependent RNA helicase DHR1.	0.937
AWRI3580_g1024	AWRI3580_g2913	A0A1E5RYA2	A0A1E5RJ90	Protein SOF1.	Putative nucleolar complex protein 14.	0.999
AWRI3580_g1024	AWRI3580_g2916	A0A1E5RYA2	A0A1E5RJ57	Protein SOF1.	Something about silencing protein 10.	0.999
AWRI3580_g1024	AWRI3580_g3619	A0A1E5RYA2	A0A1E5R9Y8	Protein SOF1.	U3 small nucleolar RNA-associated protein 14.	0.997
AWRI3580_g1024	AWRI3580_g450	A0A1E5RYA2	A0A1E5S0G6	Protein SOF1.	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family.	0.998
AWRI3580_g1024	AWRI3580_g584	A0A1E5RYA2	A0A1E5S1Q9	Protein SOF1.	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.	0.999
AWRI3580_g1024	AWRI3580_g878	A0A1E5RYA2	A0A1E5RY00	Protein SOF1.	rRNA-processing protein FCF1.	0.999
AWRI3580_g1219	AWRI3580_g1024	A0A1E5RUF2	A0A1E5RYA2	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	Protein SOF1.	0.998
AWRI3580_g1219	AWRI3580_g1278	A0A1E5RUF2	A0A1E5RUE9	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	40S ribosomal protein S9-B.	0.999
AWRI3580_g1219	AWRI3580_g1759	A0A1E5RUF2	A0A1E5RR21	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family.	0.999
AWRI3580_g1219	AWRI3580_g2306	A0A1E5RUF2	A0A1E5RPE1	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	Putative ATP-dependent RNA helicase DHR1.	0.848
AWRI3580_g1219	AWRI3580_g2913	A0A1E5RUF2	A0A1E5RJ90	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	Putative nucleolar complex protein 14.	0.997
AWRI3580_g1219	AWRI3580_g2916	A0A1E5RUF2	A0A1E5RJ57	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	Something about silencing protein 10.	0.999
AWRI3580_g1219	AWRI3580_g3619	A0A1E5RUF2	A0A1E5R9Y8	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	U3 small nucleolar RNA-associated protein 14.	0.998
AWRI3580_g1219	AWRI3580_g450	A0A1E5RUF2	A0A1E5S0G6	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family.	0.999
AWRI3580_g1219	AWRI3580_g584	A0A1E5RUF2	A0A1E5S1Q9	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.	0.999
AWRI3580_g1219	AWRI3580_g878	A0A1E5RUF2	A0A1E5RY00	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family.	rRNA-processing protein FCF1.	0.998

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Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.889

expected number of edges:

19

PPI enrichment p-value:

0.0903

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046710

GDP metabolic process

3 of 7

2.86

2.26

7.37e-05

GO:0046037

GMP metabolic process

3 of 13

2.59

2.04

0.00017

GO:0046940

Nucleoside monophosphate phosphorylation

3 of 29

2.24

1.59

0.0010

GO:0010737

Protein kinase A signaling

2 of 9

2.58

1.31

0.0041

GO:0009150

Purine ribonucleotide metabolic process

4 of 242

1.45

1.07

0.0033

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004679

AMP-activated protein kinase activity

2 of 7

2.68

0.96

0.0185

GO:0004385

Guanylate kinase activity

2 of 6

2.75

0.96

0.0185

GO:0004691

cAMP-dependent protein kinase activity

2 of 8

2.63

0.95

0.0185

GO:0004115

3,5-cyclic-AMP phosphodiesterase activity

2 of 21

2.21

0.88

0.0238

GO:0016301

Kinase activity

5 of 625

1.13

0.68

0.0185

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005952

cAMP-dependent protein kinase complex

2 of 12

2.45

0.88

0.0253

GO:0030141

Secretory granule

2 of 15

2.35

0.87

0.0253

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15653

GDP metabolic process, and Dpy-30 motif

4 of 5

3.13

4.21

2.11e-08

CL:444

Mixed, incl. Atos-like, conserved domain, and Response to mechanical stimulus

2 of 6

2.75

1.48

0.0020

CL:3205

cAMP-dependent protein kinase complex, and Protein kinase, C-terminal

2 of 24

2.15

0.91

0.0200

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

6 of 223

1.66

2.52

2.06e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-418555

G alpha (s) signalling events

4 of 31

2.34

2.82

3.40e-06

MAP-111885

Opioid Signalling

4 of 49

2.14

2.51

9.45e-06

MAP-438064

Post NMDA receptor activation events

3 of 24

2.33

2.11

9.47e-05

MAP-111997

CaM pathway

3 of 25

2.31

2.11

9.47e-05

MAP-111933

Calmodulin induced events

3 of 25

2.31

2.11

9.47e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0002177

Manchette

2 of 4

2.93

1.24

0.0057

GOCC:0001669

Acrosomal vesicle

2 of 4

2.93

1.24

0.0057

GOCC:0005952

cAMP-dependent protein kinase complex

2 of 12

2.45

1.09

0.0099

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00471

Metal dependent phosphohydrolases with conserved HD motif.

2 of 26

2.11

0.78

0.0360

SM00015

Short calmodulin-binding motif containing conserved Ile and Gln residues.

2 of 20

2.23

0.78

0.0360

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