STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AWRI3580_g1695Histone-lysine N-methyltransferase, H3 lysine-4 specific. (875 aa)    
Predicted Functional Partners:
AWRI3580_g3672
DNA damage-responsive transcriptional repressor RPH1.
   
 0.997
AWRI3580_g3793
COMPASS component SWD1.
    
 0.996
AWRI3580_g939
COMPASS component BRE2.
    
 0.996
AWRI3580_g1232
COMPASS component SWD3.
   
 0.983
AWRI3580_g3587
Histone H2A; Belongs to the histone H2A family.
    
 0.981
AWRI3580_g1842
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.953
AWRI3580_g1841
Histone H3; Belongs to the histone H3 family.
   
 0.950
AWRI3580_g1564
COMPASS component SWD2.
    
 
 0.927
AWRI3580_g634
Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.
   
 0.913
AWRI3580_g3586
Histone H2B.2; Belongs to the histone H2B family.
    
 0.910
Your Current Organism:
Hanseniaspora uvarum
NCBI taxonomy Id: 29833
Other names: ATCC 32369, CBS 314, DBVPG 6718, H. uvarum, Hanseniaspora apiculata, IFO 10833, Kloeckera apiculata, Kloeckeraspora uvarum
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.