AWRI3580_g410 protein (Hanseniaspora uvarum)

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Your Input:

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Score

AWRI3580_g410

AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (674 aa)

Predicted Functional Partners:

AWRI3580_g2546

0.999

AWRI3580_g2622

0.999

AWRI3580_g2403

0.999

AWRI3580_g871

0.964

AWRI3580_g386

0.963

AWRI3580_g256

0.934

AWRI3580_g2009

0.902

AWRI3580_g253

0.894

AWRI3580_g2879

0.805

AWRI3580_g2880

0.805

Your Current Organism:

Hanseniaspora uvarum

NCBI taxonomy Id: 29833
Other names: ATCC 32369, CBS 314, DBVPG 6718, H. uvarum, Hanseniaspora apiculata, IFO 10833, Kloeckera apiculata, Kloeckeraspora uvarum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AWRI3580_g2009	AWRI3580_g2403	A0A1E5RQ76	A0A1E5RQY3	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.	AP-1 complex subunit mu-1-I; Belongs to the adaptor complexes medium subunit family.	0.840
AWRI3580_g2009	AWRI3580_g253	A0A1E5RQ76	A0A1E5S0A6	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.770
AWRI3580_g2009	AWRI3580_g2546	A0A1E5RQ76	A0A1E5RIF3	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.	AP-1 complex subunit gamma.	0.490
AWRI3580_g2009	AWRI3580_g2622	A0A1E5RQ76	A0A1E5RIT3	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.892
AWRI3580_g2009	AWRI3580_g2879	A0A1E5RQ76	A0A1E5RJU4	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.	ADP-ribosylation factor; Belongs to the small GTPase superfamily. Arf family.	0.559
AWRI3580_g2009	AWRI3580_g2880	A0A1E5RQ76	A0A1E5RJY0	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.	ADP-ribosylation factor; Belongs to the small GTPase superfamily. Arf family.	0.559
AWRI3580_g2009	AWRI3580_g386	A0A1E5RQ76	A0A1E5S0P6	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.	Adaptin medium chain APM2; Belongs to the adaptor complexes medium subunit family.	0.840
AWRI3580_g2009	AWRI3580_g410	A0A1E5RQ76	A0A1E5S0I8	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.902
AWRI3580_g2009	AWRI3580_g871	A0A1E5RQ76	A0A1E5RXN7	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.805
AWRI3580_g2403	AWRI3580_g2009	A0A1E5RQY3	A0A1E5RQ76	AP-1 complex subunit mu-1-I; Belongs to the adaptor complexes medium subunit family.	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.	0.840
AWRI3580_g2403	AWRI3580_g253	A0A1E5RQY3	A0A1E5S0A6	AP-1 complex subunit mu-1-I; Belongs to the adaptor complexes medium subunit family.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.869
AWRI3580_g2403	AWRI3580_g2546	A0A1E5RQY3	A0A1E5RIF3	AP-1 complex subunit mu-1-I; Belongs to the adaptor complexes medium subunit family.	AP-1 complex subunit gamma.	0.999
AWRI3580_g2403	AWRI3580_g2622	A0A1E5RQY3	A0A1E5RIT3	AP-1 complex subunit mu-1-I; Belongs to the adaptor complexes medium subunit family.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.999
AWRI3580_g2403	AWRI3580_g2879	A0A1E5RQY3	A0A1E5RJU4	AP-1 complex subunit mu-1-I; Belongs to the adaptor complexes medium subunit family.	ADP-ribosylation factor; Belongs to the small GTPase superfamily. Arf family.	0.762
AWRI3580_g2403	AWRI3580_g2880	A0A1E5RQY3	A0A1E5RJY0	AP-1 complex subunit mu-1-I; Belongs to the adaptor complexes medium subunit family.	ADP-ribosylation factor; Belongs to the small GTPase superfamily. Arf family.	0.762
AWRI3580_g2403	AWRI3580_g386	A0A1E5RQY3	A0A1E5S0P6	AP-1 complex subunit mu-1-I; Belongs to the adaptor complexes medium subunit family.	Adaptin medium chain APM2; Belongs to the adaptor complexes medium subunit family.	0.467
AWRI3580_g2403	AWRI3580_g410	A0A1E5RQY3	A0A1E5S0I8	AP-1 complex subunit mu-1-I; Belongs to the adaptor complexes medium subunit family.	AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.999
AWRI3580_g2403	AWRI3580_g871	A0A1E5RQY3	A0A1E5RXN7	AP-1 complex subunit mu-1-I; Belongs to the adaptor complexes medium subunit family.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.858
AWRI3580_g253	AWRI3580_g2009	A0A1E5S0A6	A0A1E5RQ76	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.	0.770
AWRI3580_g253	AWRI3580_g2403	A0A1E5S0A6	A0A1E5RQY3	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	AP-1 complex subunit mu-1-I; Belongs to the adaptor complexes medium subunit family.	0.869

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Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019509

L-methionine salvage from methylthioadenosine

5 of 10

2.78

4.68

1.65e-09

GO:0019284

L-methionine salvage from S-adenosylmethionine

3 of 6

2.78

2.69

1.12e-05

GO:0044283

Small molecule biosynthetic process

6 of 545

1.12

1.03

0.00041

GO:0005996

Monosaccharide metabolic process

3 of 129

1.45

0.78

0.0220

GO:0019752

Carboxylic acid metabolic process

6 of 788

0.96

0.75

0.0026

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043874

Acireductone synthase activity

2 of 2

3.08

1.18

0.0074

GO:0043716

2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity

2 of 2

3.08

1.18

0.0074

GO:0043715

2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity

2 of 2

3.08

1.18

0.0074

GO:0010309

Acireductone dioxygenase [iron(II)-requiring] activity

2 of 2

3.08

1.18

0.0074

GO:0010308

Acireductone dioxygenase (Ni2+-requiring) activity

2 of 2

3.08

1.18

0.0074

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20301

Amino acid salvage, and ribitol-5-phosphatase activity

7 of 12

2.85

7.61

2.79e-15

CL:20303

L-methionine salvage from S-adenosylmethionine, and Acireductone dioxygenase ARD family

3 of 6

2.78

2.59

1.73e-05

CL:16299

Glycolytic process, and Pentose phosphate pathway

4 of 59

1.91

2.02

6.01e-05

CL:16407

Mixed, incl. Ribokinase, and Xylulose metabolic process

2 of 5

2.68

1.37

0.0032

CL:16313

Glycolytic process

2 of 19

2.1

0.86

0.0244

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00270

Cysteine and methionine metabolism

6 of 108

1.83

3.1

2.45e-08

map01100

Metabolic pathways

11 of 3633

0.56

0.49

5.09e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1237112

Methionine salvage pathway

5 of 7

2.94

5.37

1.03e-10

MAP-1614635

Sulfur amino acid metabolism

5 of 36

2.22

3.57

4.81e-08

MAP-71291

Metabolism of amino acids and derivatives

5 of 400

1.18

0.91

0.0030

MAP-71387

Metabolism of carbohydrates

4 of 333

1.16

0.67

0.0227

MAP-1430728

Metabolism

9 of 2436

0.65

0.49

0.0030

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0486

Methionine biosynthesis

3 of 8

2.66

2.57

1.75e-05

KW-0223

Dioxygenase

2 of 9

2.43

1.37

0.0029

KW-0119

Carbohydrate metabolism

2 of 17

2.15

1.16

0.0067

KW-0963

Cytoplasm

3 of 180

1.3

0.75

0.0197

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR027496

Acireductone dioxygenase, eukaryotes

2 of 2

3.08

0.96

0.0186

IPR004313

Acireductone dioxygenase ARD family

2 of 2

3.08

0.96

0.0186

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