AWRI3580_g299 protein (Hanseniaspora uvarum)

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

AWRI3580_g299

Uncharacterized protein. (746 aa)

Predicted Functional Partners:

AWRI3580_g2264

0.696

AWRI3580_g1041

0.696

AWRI3580_g2057

0.643

AWRI3580_g2084

0.490

AWRI3580_g1960

0.454

AWRI3580_g1352

0.419

AWRI3580_g3851

0.417

AWRI3580_g3059

0.417

AWRI3580_g1350

0.417

AWRI3580_g2375

0.407

Your Current Organism:

Hanseniaspora uvarum

NCBI taxonomy Id: 29833
Other names: ATCC 32369, CBS 314, DBVPG 6718, H. uvarum, Hanseniaspora apiculata, IFO 10833, Kloeckera apiculata, Kloeckeraspora uvarum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AWRI3580_g1041	AWRI3580_g2057	A0A1E5RYC3	A0A1E5RPX0	Acyl-CoA desaturase 1.	Cytochrome b2, mitochondrial.	0.862
AWRI3580_g1041	AWRI3580_g2264	A0A1E5RYC3	A0A1E5RR95	Acyl-CoA desaturase 1.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.898
AWRI3580_g1041	AWRI3580_g299	A0A1E5RYC3	A0A1E5S220	Acyl-CoA desaturase 1.	Uncharacterized protein.	0.696
AWRI3580_g1350	AWRI3580_g1352	A0A1E5RUU7	A0A1E5RVG8	DNA-directed RNA polymerase II subunit RPB7.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
AWRI3580_g1350	AWRI3580_g2375	A0A1E5RUU7	A0A1E5RPS4	DNA-directed RNA polymerase II subunit RPB7.	DNA-directed RNA polymerase II subunit RPB3.	0.999
AWRI3580_g1350	AWRI3580_g299	A0A1E5RUU7	A0A1E5S220	DNA-directed RNA polymerase II subunit RPB7.	Uncharacterized protein.	0.417
AWRI3580_g1350	AWRI3580_g3059	A0A1E5RUU7	A0A1E5RJQ2	DNA-directed RNA polymerase II subunit RPB7.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.999
AWRI3580_g1350	AWRI3580_g3851	A0A1E5RUU7	A0A1E5R4I1	DNA-directed RNA polymerase II subunit RPB7.	DNA-directed RNA polymerases I, II, and III subunit RPABC1.	0.999
AWRI3580_g1352	AWRI3580_g1350	A0A1E5RVG8	A0A1E5RUU7	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	DNA-directed RNA polymerase II subunit RPB7.	0.999
AWRI3580_g1352	AWRI3580_g2375	A0A1E5RVG8	A0A1E5RPS4	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	DNA-directed RNA polymerase II subunit RPB3.	0.999
AWRI3580_g1352	AWRI3580_g299	A0A1E5RVG8	A0A1E5S220	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Uncharacterized protein.	0.419
AWRI3580_g1352	AWRI3580_g3059	A0A1E5RVG8	A0A1E5RJQ2	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.999
AWRI3580_g1352	AWRI3580_g3851	A0A1E5RVG8	A0A1E5R4I1	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	DNA-directed RNA polymerases I, II, and III subunit RPABC1.	0.999
AWRI3580_g1960	AWRI3580_g299	A0A1E5RRA7	A0A1E5S220	Sphingolipid long chain base-responsive protein PIL1.	Uncharacterized protein.	0.454
AWRI3580_g2057	AWRI3580_g1041	A0A1E5RPX0	A0A1E5RYC3	Cytochrome b2, mitochondrial.	Acyl-CoA desaturase 1.	0.862
AWRI3580_g2057	AWRI3580_g2264	A0A1E5RPX0	A0A1E5RR95	Cytochrome b2, mitochondrial.	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	0.862
AWRI3580_g2057	AWRI3580_g299	A0A1E5RPX0	A0A1E5S220	Cytochrome b2, mitochondrial.	Uncharacterized protein.	0.643
AWRI3580_g2084	AWRI3580_g299	A0A1E5RPD4	A0A1E5S220	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	Uncharacterized protein.	0.490
AWRI3580_g2264	AWRI3580_g1041	A0A1E5RR95	A0A1E5RYC3	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	Acyl-CoA desaturase 1.	0.898
AWRI3580_g2264	AWRI3580_g2057	A0A1E5RR95	A0A1E5RPX0	Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.	Cytochrome b2, mitochondrial.	0.862

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Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.852

expected number of edges:

13

PPI enrichment p-value:

0.0832

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035601

Protein deacylation

2 of 22

2.23

1.18

0.0155

GO:0006357

Regulation of transcription by RNA polymerase II

5 of 470

1.3

1.09

0.0030

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004407

Histone deacetylase activity

2 of 9

2.62

1.12

0.0213

GO:0000977

RNA polymerase II transcription regulatory region sequence-specific DNA binding

3 of 95

1.77

1.01

0.0213

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

3 of 233

1.38

0.8

0.0315

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9511

Mixed, incl. Homeobox, and CCAAT-binding factor complex

3 of 27

2.31

2.01

0.00071

CL:2967

Rpd3S/Clr6-CII complex, and Sds3-like

2 of 6

2.79

1.66

0.0034

CL:9514

Mixed, incl. Homeobox, and Senescence-Associated Secretory Phenotype (SASP)

2 of 17

2.34

1.22

0.0140

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04213

Longevity regulating pathway - multiple species

2 of 11

2.53

1.67

0.0030

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00850

Histone deacetylase domain

2 of 4

2.97

1.62

0.0040

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003084

Histone deacetylase

2 of 2

3.27

1.59

0.0045

IPR000286

Histone deacetylase family

2 of 3

3.09

1.59

0.0045

IPR037138

Histone deacetylase domain superfamily

2 of 4

2.97

1.58

0.0045

IPR023801

Histone deacetylase domain

2 of 4

2.97

1.58

0.0045

IPR023696

Ureohydrolase domain superfamily

2 of 10

2.57

1.34

0.0098

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