Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Z5494Putative cystathionine gamma-synthase; Predicted by orpheus program; predicted by glimmer program. (388 aa)    
Predicted Functional Partners:
STM4101
Putative aspartokinase II/homoserine dehydrogenase, methionine-sensitive; Predicted by orpheus program; predicted by glimmer program; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.987
C2948
Putative cysteine synthase A; Predicted by orpheus program; predicted by glimmer program; Belongs to the cysteine synthase/cystathionine beta- synthase family.
 
 0.986
SCO1028
Putative cysteine synthase/cystathionine (CysK); Predicted by orpheus program; predicted by glimmer program.
 
 0.980
METH
Putative cobalamin-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.978
C4970
Putative homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family.
 
 
 0.977
METE
Putative 5-Methyltetrahydropteroyltriglutamate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.965
BH3313
Putative PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities; Predicted by orpheus program; predicted by glimmer program.
 
 
 0.954
S2901
Putative autoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
 
 
 0.954
S2972
Putative sulfite reductase (NADPH) hemoprotein beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
  
 
 0.945
Y3718
Putative aspartokinase I/homoserine dehydrogenase; Predicted by orpheus program; predicted by glimmer program; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.943
Your Current Organism:
Photobacterium profundum
NCBI taxonomy Id: 298386
Other names: P. profundum SS9, Photobacterium SS9, Photobacterium profundum SS9, Photobacterium profundum str. SS9, Photobacterium profundum strain SS9, Photobacterium sp. (strain SS9), Photobacterium sp. SS9, deep-sea eubacterium SS9
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